Target safety assessments and their role in de-risking drug discovery – Nav1.7 as an example
Target safety assessments and their role in de-risking drug discovery – Nav1.7 as an example

Target Safety Assessments, Publications, TSA Page

Target safety assessments and their role in de-risking drug discovery – Nav1.7 as an example

This poster, presented at the Gordon Research Conference in August 2017, concluded that: Target safety assessments: Provide expert assessment and interpretation of literature and available databases and are invaluable in identifying and avoiding target-related risks Inform target selection and/or prioritisation early in discovery Should contain the level of detail appropriate to the project stage Should [...]

By Ruth Roberts|2022-11-22T16:22:21+00:00August 20th, 2017|Target Safety Assessments, Publications, TSA Page|Comments Off

Target Safety Assessments: Strategies and Resources
Target Safety Assessments: Strategies and Resources

Target Safety Assessments, Publications, TSA Page

Target Safety Assessments: Strategies and Resources

Target Safety Assessment: Strategies and Resources, Chapter 12 of Drug Safety Evaluation Methods in Molecular Biology (vol 1641), was written by Dr Richard J Brennan, a Scientific Advisor at Sanofi in the United States. The chapter presents a summary of the information types and sources that should be investigated and approaches that can be [...]

By Ruth Roberts|2023-04-18T16:44:27+01:00July 27th, 2017|Target Safety Assessments, Publications, TSA Page|Comments Off

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.
Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.

Toxicology, Publications

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.

Abstract Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic/prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover [...]

By Claire Sadler|2022-07-13T15:31:40+01:00April 27th, 2017|Toxicology, Publications|Comments Off

Who’s in the Top 10% of Articles in Toxicological Sciences?
Who’s in the Top 10% of Articles in Toxicological Sciences?

Toxicology, Publications

Who’s in the Top 10% of Articles in Toxicological Sciences?

Ruth Roberts is first author on one of Toxicological Sciences’ top 10% downloaded articles during the last 2 years. The paper, ‘Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward’ describes the challenges and opportunities in the development of biomarkers of neurotoxicity, a goal shared by scientists across academia, [...]

By Ruth Roberts|2021-11-30T12:59:17+00:00March 24th, 2017|Toxicology, Publications|Comments Off

“Most Downloaded Article” award for Jane Stewart!
“Most Downloaded Article” award for Jane Stewart!

Toxicology, Publications

“Most Downloaded Article” award for Jane Stewart!

ApconiX Associate Jane Stewart is first author on a manuscript in the DIA peer-reviewed journal “Therapeutic Innovation and Regulatory Science” (TIRS) that has received the DIA’s 2017 Author of the Year Award. This annual award honours the author of the most accessed and downloaded article in TIRS. The article ‘Birth Control in Clinical Trials: [...]

By Ruth Roberts|2025-08-20T15:13:58+01:00February 15th, 2017|Toxicology, Publications|Comments Off

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase
Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Toxicology, Publications

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase Abstract We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition of decaprenylphosphoryl-β-d-ribose 2′-oxidase [...]

By Claire Sadler|2023-05-30T15:17:48+01:00December 24th, 2015|Toxicology, Publications|Comments Off

Target organ profiles in toxicity studies supporting human dosing: Does severity progress with longer duration of exposure?
Target organ profiles in toxicity studies supporting human dosing: Does severity progress with longer duration of exposure?

Toxicology, Publications

Target organ profiles in toxicity studies supporting human dosing: Does severity progress with longer duration of exposure?

Target organ profiles in toxicity studies supporting human dosing: Does severity progress with longer duration of exposure? Abstract: We have previously reported the profile of target organs (defined as organs showing histopathological changes) in rodent and non-rodent toxicity studies conducted prior to first-time-in-man (FTiM) for 77 AstraZeneca candidate drugs [...]

By Richard Knight|2023-01-18T15:10:02+00:00December 1st, 2015|Toxicology, Publications|Comments Off

A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERD’s).
A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERD’s).

Publications

A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERD’s).

A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERD’s). Abstract Here, we describe an approach to identify novel selective estrogen receptor downregulator (SERD) compounds with improved properties such as oral bioavailability and the potential of increased efficacy compared to currently marketed drug treatments. Previously, [...]

By Karen Jones|2023-01-18T14:54:36+00:00December 1st, 2015|Publications|Comments Off

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.
Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.

Publications

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging.

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging. Abstract We describe the use of a commercially available high content cell imaging algorithm (Cellomics Arrayscan Spot Detector) to quantify biliary excretion of the fluorescent probe substrate cholyl-l-lysyl-fluorescein (CLF) from rat hepatocytes cultured in [...]

By Jane Barber|2023-01-18T15:07:20+00:00November 30th, 2015|Publications|Comments Off

Publishing is the lifeblood of science – so what’s stopping you?
Publishing is the lifeblood of science – so what’s stopping you?

Publications

Publishing is the lifeblood of science – so what’s stopping you?

Publishing is the lifeblood of science I love writing papers. I really enjoy the combination of creativity and logic required plus the sense of drawing a line under a piece of work. It’s also great (usually!) to get feedback from the scientific community both during and after the peer [...]

By Ruth Roberts|2026-06-02T11:17:33+01:00November 5th, 2015|Publications|Comments Off

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