The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity.

Read more here: RA Cardarelli, K Jones, LI Pisella, HJ Wobst, LJ McWilliams, PM Sharpe, MP Burnham, DJ Baker, I Chudotvorova, J Guyot, L Silayeva, DH Morrow, N Dekker, S Zicha, PA Davies, J Holenz, ME Duggan, J Dunlop, RJ Mather, Q Wang, I Medina, NJ Brandon, TZ Deeb and SJ Moss. The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity. Nat Med. 23(12):1394-1396. 2017. 

By |2018-07-11T14:46:53+00:00December 1st, 2017|Ion Channels, Publications|Comments Off on The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity.

About the Author:

Dr Karen Jones graduated from the University of Liverpool with a degree in Pharmacology. After researching the basis for naphthoquinone and biguanide synergy, Karen also gained her PhD from the University of Liverpool. Karen worked at Astra Zeneca for some 14 years, most recently as project lead for multiple high throughput screening campaigns supporting projects in a range of disease areas including Neuroscience, Oncology, Cardiovascular and Metabolic disease. Previously to this Karen delivered high quality data from multiple in vitro assay formats, developed ion channel assays used to screen multiple ion channel targets, always improving procedures where possible and driving forward projects by focusing on quality and robustness.