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The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity.
  • View Larger Image CLP257

Read more here: RA Cardarelli, K Jones, LI Pisella, HJ Wobst, LJ McWilliams, PM Sharpe, MP Burnham, DJ Baker, I Chudotvorova, J Guyot, L Silayeva, DH Morrow, N Dekker, S Zicha, PA Davies, J Holenz, ME Duggan, J Dunlop, RJ Mather, Q Wang, I Medina, NJ Brandon, TZ Deeb and SJ Moss. The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity. Nat Med. 23(12):1394-1396. 2017. 

By Karen Jones|2024-09-23T15:22:17+01:00December 1st, 2017|Publications, Ion Channels|Comments Off on The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity.

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About the Author: Karen Jones

Dr Karen Jones PhD. Karen is a Senior Research Scientist with over 10 years of experience in the pharmaceutical industry within the early drug discovery setting. Karen’s area of expertise is in the development of Ion Channel and GPCR assays which are used for compound screening in various formats from small scale bespoke experiments up to large scale fully automated screens. Karen is skilled at problem solving and has a proven track record of delivery with difficult targets leading to publications in peer reviewed journals.

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