Understanding drug targets: no such thing as bad news

Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated with proposed drug targets is a crucial element in understanding the unwanted side-effects that might stop a project in [...]

By | 2018-06-13T16:08:37+00:00 June 6th, 2018|Toxicology, Publications|Comments Off on Understanding drug targets: no such thing as bad news

Ruth wins the 2018 SOT Founders Award!

The official photographs are out to show that it was all smiles in San Antonio earlier this year when I received the 2018 Society of Toxicology (SOT) founders award.  I was proud to be presented with the  plaque by my good friend and colleague, Leigh Ann Burns Naas.  Dr Burns Naas is SOT President as [...]

By | 2018-05-30T13:46:49+00:00 May 24th, 2018|Events|Comments Off on Ruth wins the 2018 SOT Founders Award!

Safety Must Be Prioritized In Drugs for Cancer

Despite the fact that the number of diagnosed cases of malignant mesothelioma are expected to rise in the next decades, there has been little real progress in available treatments, and the chemotherapy drug used to treat the disease is the same one that has been used for the last several  years. Though there is a [...]

By | 2018-05-23T16:46:08+00:00 May 16th, 2018|Press|Comments Off on Safety Must Be Prioritized In Drugs for Cancer

RSB Presidents Dinner

Ruth Roberts (ApconiX) and Emma Walker (Kings College London) attended the Royal Society of Biology President's Dinner May 2nd 2018 where they chatted with Stephen Benn about the great work he does as Vice-President of the Parliamentary and Scientific Committee and for the Society as their Director of Parliamentary Affairs. Professor Dame Julia Goodfellow succeeded [...]

By | 2018-05-30T14:40:15+00:00 May 9th, 2018|Events|Comments Off on RSB Presidents Dinner

ApconiX @ The BTS Congress 2018!

We were delighted to sponsor the poster and drinks reception at the annual British Toxicology Society meeting April 2018. The posters were fascinating with lots of new data on topics such as differentiated pluripotent stem cells, predicting and avoiding drug-induced toxicity and characterisation of cardiac stem cells for assessment of cardiotoxicity.  There were also some [...]

By | 2018-05-23T16:40:25+00:00 April 18th, 2018|Events|Comments Off on ApconiX @ The BTS Congress 2018!

Xenogesis & Sygnature Hosted Meeting

ApconiX enjoyed a double-billing at the recent ‘Predictive Toxicology in Discovery DMPK’ meeting hosted by Sygnature Discovery and Xenogesis in Nottingham.  Ruth Roberts kicked off the event with the keynote address entitled ‘Roberts Derisking early drug projects Shortened Version March 2018’ (click the title for pdf).  Mike Morton addressed the conference later on in the [...]

By | 2018-06-06T15:26:57+00:00 March 23rd, 2018|Events|Comments Off on Xenogesis & Sygnature Hosted Meeting

Post SOT ApconiX Post!

Team ApconiX (Ruth Roberts, Richard Knight, Mike Morton, Paul Duffy and Claire Sadler) had a truly outstanding SOT2018 with great new science and great new contacts.  Ruth Roberts was the proud recipient of the 2018 SOT Founders Award presented by SOT president Patti Ganey.  Claire Sadler presented in a session on Elevator Pitch followed by [...]

By | 2018-06-13T09:12:34+00:00 March 19th, 2018|Events|Comments Off on Post SOT ApconiX Post!

Team ApconiX will be @ SOT2018!

Ruth Roberts, Richard Knight, Mike Morton, Paul Duffy and Claire Sadler will be at SOT2018.  We’d love to talk to you about how ApconiX can add value to your projects through better decisions in project toxicology, target safety assessments and ion channel/hERG screening.  Every project is unique and needs the guidance of experts to ensure [...]

By | 2018-06-06T14:46:29+00:00 March 8th, 2018|Events|Comments Off on Team ApconiX will be @ SOT2018!

ApconiX Return Over 80% of hERG Screening Data to Clients Within One Week

Why is Time Critical to hERG Screening Data? ApconiX has worked hard to optimise our processes and is now returning over 80% of hERG screening data back to clients within one week of compound receipt.  This allows critical decisions to be made in medicinal chemistry on a full dataset of compound properties, avoiding mistakes and [...]

By | 2018-06-21T16:30:26+00:00 March 5th, 2018|Ion Channels|Comments Off on ApconiX Return Over 80% of hERG Screening Data to Clients Within One Week

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Abstract: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on [...]

By | 2018-06-13T16:07:16+00:00 February 28th, 2018|Toxicology, Publications|Comments Off on Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.