Target Safety Reports: What’s in a Name?

Irrespective of what we call them, target safety reports form a key part of risk assessment and risk mitigation plans in drug discovery and development. Why is that?  Well, target-related toxicity accounts for >50% of all drug project failures (Cook et al., 2014) so it’s vital to understand the potential unintended consequences of target modulation.  [...]

By |2018-10-12T14:15:50+00:00October 12th, 2018|Target Safety Assessments|Comments Off on Target Safety Reports: What’s in a Name?

ApconiX Welcomes Bethany Russell

Bethany joins ApconiX as a placement student for part of September.  A second-year student, Bethany is studying Biomedical Sciences at Sheffield University.  Her degree is a four-year sandwich course, with a third-year placement in industry. Bethany was unsure if a career in a laboratory was for her and wanted to be clearer before making her [...]

By |2018-09-25T18:03:38+00:00October 4th, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes Bethany Russell

Collaboration and competition: ethics in toxicology

What are our attitudes to research resourcing, publication and the peer review system?  The British Toxicology Society (BTS) is conducting a survey to establish attitudes of toxicologists to key questions such as ‘I believe collaboration to be important in driving toxicology research in the UK’ and ‘I believe the current system of peer review for [...]

By |2018-09-27T18:18:55+00:00September 27th, 2018|Toxicology|Comments Off on Collaboration and competition: ethics in toxicology

ApconiX is supporting PhysioStim at SPS

ApconiX and PhysioStim will be celebrating their first year of The European Centre of Excellence for preclinical cardiovascular electrophysiology at the Safety Pharmacology Society Annual Meeting in Washington this September.  ApconiX will be supporting PhysioStim as they exhibit at the Marriott Wardman Park Hotel on Stand 412 from the 30th of September to the 3rd [...]

By |2018-09-25T18:23:43+00:00September 26th, 2018|Ion Channels, Events|Comments Off on ApconiX is supporting PhysioStim at SPS

Choosing the right non-clinical CRO

Non-clinical contract research organisations (CROs) are an integral part of modern drug development. For any novel agent, delivery of GLP toxicity data to support clinical trials is a crucial step that requires a professional organisation with dedicated management, infrastructure and a broad array of technical and scientific skills. In selecting a CRO, the sponsor typically [...]

By |2018-09-12T14:07:14+00:00September 19th, 2018|Toxicology, Press|Comments Off on Choosing the right non-clinical CRO

ApconiX Celebrates EUROTOX

EUROTOX 2018 was a great success with many excellent sessions, posters and keynote lectures.  There were more than 1400 attendees from >50 countries giving an outstanding opportunity for networking and learning. Highlights included the Merit award lecture from Sam Cohen (University of Nebraska) who talked about “Cell proliferation and carcinogenesis” and the HESI CITE lecture [...]

By |2018-09-13T08:39:22+00:00September 12th, 2018|Events|Comments Off on ApconiX Celebrates EUROTOX

Michael Morton Presents at EUROTOX 2018

Dr Michael Morton will be speaking at EUROTOX this September in Belgium.  On Tuesday September 4th at 16:30 in Hall 100 Mike will address ‘Cardiac safety: current state of the art’ chaired by Dr Mark Holbrook of VAST Pharma solutions and Ester Lovsin-Barle from Lonza.  Mike will present ‘Ion channel profiling of stem cell-derived cardiomyocytes: [...]

By |2018-08-23T12:05:35+00:00August 29th, 2018|Ion Channels, Events|Comments Off on Michael Morton Presents at EUROTOX 2018

Paul Duffy Presents at EUROTOX 2018

Dr Paul Duffy will be speaking at EUROTOX this September. On Monday 3rd of September at 16:30 in the SILVER Hall Paul will address “Old drugs in new guises: the toxicology of repurposing” chaired and introduced by Ruth Roberts and Dr Miranda Cornet from UCB in Belgium.  Paul will present case studies to illustrate the [...]

By |2018-08-23T12:05:58+00:00August 22nd, 2018|Toxicology, Events|Comments Off on Paul Duffy Presents at EUROTOX 2018

ApconiX at EUROTOX 2018

Dr Michael Morton, Professor Ruth Roberts, Dr Richard Knight and Dr Paul Duffy will be attending EUROTOX this September in Brussels. The theme for 2018 is “Toxicology Out of the Box” and reflects the federation’s willingness and enthusiasm to offer an innovative, forward-looking and imaginative scientific programme.  ‘"The theme for EUROTOX aligns perfectly with our [...]

By |2018-08-15T09:24:31+00:00August 15th, 2018|Toxicology, Events|Comments Off on ApconiX at EUROTOX 2018

ApconiX Welcomes George Buchanan

George joins ApconiX as a placement student for the month of August.  George graduated from the University of Newcastle last year after studying Biology.  He decided to take a year out before beginning a master’s degree in stem cell technology and regenerative medicine at the University of Nottingham in September. George was keen to gain [...]

By |2018-07-31T13:02:03+00:00July 31st, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes George Buchanan