Cardiac Safety in Drug Development: CiPA

In the second of a three-part series looking at cardiac safety testing in early drug discovery, Dr Michael Morton of ApconiX considers the CiPA initiative and how its integrated approach sits alongside existing strategies. What is the CiPA initiative and what does it mean for drug discovery? In the first blog, we outlined the background [...]

By |2020-02-19T13:03:20+00:00February 19th, 2020|Ion Channels|Comments Off on Cardiac Safety in Drug Development: CiPA

My Brush with Greatness

It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this time, Neher and Sakmann had recruited a Post Doc called [...]

By |2020-01-30T14:21:05+00:00January 16th, 2020|Ion Channels|Comments Off on My Brush with Greatness

An Ascorbate-Induced Increase in Sodium Current

The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles.  Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, ascorbic acid. The Science Firstly, it was important to examine any potential [...]

By |2020-01-30T14:52:24+00:00January 16th, 2020|Ion Channels|Comments Off on An Ascorbate-Induced Increase in Sodium Current

Innovative Models for In Vitro Detection of Seizure

ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer the opportunity to screen for seizure liability in vitro, avoiding costly failures in preclinical [...]

By |2019-11-20T15:45:04+00:00November 20th, 2019|Ion Channels, Publications|Comments Off on Innovative Models for In Vitro Detection of Seizure

Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting

Dr Michael Morton, Director and Co-Founder will be speaking at the 10th  Nanion User Meeting on Thursday 17th of October, "Two Years of Experience and Learning with Patchliner".  The User Meeting is being held from Wednesday 17th to Thursday 18th of October at Nanion’s headquarters in Munich. Founded in 2002, Nanion has grown to be [...]

By |2019-10-13T17:50:37+01:00October 13th, 2019|Ion Channels, Events|Comments Off on Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting

ApconiX Conduct Pilot Study with Axion Biosystems

We were thrilled to welcome Jayne Ingram from Axion Biosystems into the ApconiX laboratory to conduct a pilot study using their Maestro Pro multielectrode array (MEA) system and Ncardia iPSC-derived neuronal cells.  The cells were cultured for three weeks before Jayne arrived to allow the formation of neuronal networks, which would allow us to assess [...]

By |2019-10-10T10:10:14+01:00October 10th, 2019|Ion Channels, Toxicology|Comments Off on ApconiX Conduct Pilot Study with Axion Biosystems

ApconiX Are in Boston, USA at the End of August

Dr Richard Knight and Professor Ruth Roberts are travelling to Boston at the end of August to meet with old colleagues and new contacts, promoting the company’s services in Project Toxicology, Ion Channel Screening and Assay Development, Target Safety Assessments and all aspects of Nonclinical Programme Design. They will be joined by Dr Andrew Winkley. [...]

By |2019-08-20T17:40:25+01:00August 20th, 2019|Ion Channels, Target Safety Assessments, Toxicology, Events|Comments Off on ApconiX Are in Boston, USA at the End of August

The Reductionist Approach

The hERG assay has been a mainstay of safety screening in drug discovery for the last 2 decades. Aided by the development of high throughput automated technology, this important assay has brought unparalleled progress in our ability to design safer drugs without those properties that may lead to life-threatening cardiac arrhythmia. In a series of [...]

By |2019-07-24T14:41:23+01:00July 11th, 2019|Ion Channels|Comments Off on The Reductionist Approach

ApconiX Welcomes Priscilla Dumenu

ApconiX is delighted to welcome Priscilla Dumenu for a 2-week placement.  Priscilla will be working alongside Dr Michael Morton and Dr Karen Jones in the Ion Channel laboratory. Priscilla has just finished her second year studying Pharmacy at the University of Manchester.  The 5-year integrated master’s degree includes a placement year in a community or [...]

By |2019-06-28T18:12:07+01:00June 28th, 2019|Ion Channels, Careers|Comments Off on ApconiX Welcomes Priscilla Dumenu