K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Dr Michael Morton co-authored a paper recently published in the Journal of Cardiovascular Electrophysiology. The paper should serve as a reminder that ion channels which may not be the focus of regulatory guidance or the latest CiPA initiative, still play a critical role in cardiac function, and shouldn’t be forgotten. TASK‐1 (K2P3.1) is a member [...]

By |2019-04-18T10:09:25+01:00April 18th, 2019|Ion Channels, Publications|Comments Off on K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

SOT 58th Annual Meeting & ToxExpo – 2588: Talk by Dr Michael Morton of ApconiX

At the Society of Toxicology 58th Annual Meeting and ToxExpo from March 10th to 14th at the Baltimore Convention Center, Dr Michael Morton of ApconiX will be giving a talk as part of the workshop "Can we panelize seizure?".  On Wednesday March 13th 9:30am – 10:00am in the Convention Center Ballroom III.  An Innovations in Applied [...]

By |2019-03-06T11:22:16+01:00March 6th, 2019|Ion Channels, Events|Comments Off on SOT 58th Annual Meeting & ToxExpo – 2588: Talk by Dr Michael Morton of ApconiX

SOT 58th Annual Meeting & ToxExpo – 2072: Poster Presentation by Richard Printemps of PhysioStim

At the Society of Toxicology 58th Annual Meeting and ToxExpo from March 10th to 14th at the Baltimore Convention Center, poster presentation by Richard Printemps of PhysioStim on Tuesday March 12th 3:00pm - 4:30pm Poster Board P463 Convention Center Exhibition Hall.  Incorporating the CiPA Paradigm into an Integrated Cardiac Risk Assessment. Authors:  M. Morton1, R. Printemps2, M. [...]

By |2019-03-05T14:42:32+01:00March 5th, 2019|Ion Channels, Events|Comments Off on SOT 58th Annual Meeting & ToxExpo – 2072: Poster Presentation by Richard Printemps of PhysioStim

ApconiX Opens a New Office in Sweden

ApconiX is excited to announce the opening of our new office in Sweden.  The subsidiary ApconiX AB will be located at AstraZeneca’s BioVentureHub in Gothenburg. ApconiX was formed by Dr Richard Knight, Dr Michael Morton and Professor Ruth Roberts in 2015 and is based at Alderley Park in Cheshire, U.K.   The co-founders have established a [...]

By |2019-02-27T14:36:25+01:00February 7th, 2019|Ion Channels, Target Safety Assessments, Toxicology, Events|Comments Off on ApconiX Opens a New Office in Sweden

ApconiX Welcomes Bethany Russell

Bethany joins ApconiX as a placement student for part of September.  A second-year student, Bethany is studying Biomedical Sciences at Sheffield University.  Her degree is a four-year sandwich course, with a third-year placement in industry. Bethany was unsure if a career in a laboratory was for her and wanted to be clearer before making her [...]

By |2018-11-28T15:30:09+01:00October 4th, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes Bethany Russell

ApconiX is supporting PhysioStim at SPS

ApconiX and PhysioStim will be celebrating their first year of The European Centre of Excellence for preclinical cardiovascular electrophysiology at the Safety Pharmacology Society Annual Meeting in Washington this September.  ApconiX will be supporting PhysioStim as they exhibit at the Marriott Wardman Park Hotel on Stand 412 from the 30th of September to the 3rd [...]

By |2018-09-25T18:23:43+01:00September 26th, 2018|Ion Channels, Events|Comments Off on ApconiX is supporting PhysioStim at SPS

Michael Morton Presents at EUROTOX 2018

Dr Michael Morton will be speaking at EUROTOX this September in Belgium.  On Tuesday September 4th at 16:30 in Hall 100 Mike will address ‘Cardiac safety: current state of the art’ chaired by Dr Mark Holbrook of VAST Pharma solutions and Ester Lovsin-Barle from Lonza.  Mike will present ‘Ion channel profiling of stem cell-derived cardiomyocytes: [...]

By |2018-08-23T12:05:35+01:00August 29th, 2018|Ion Channels, Events|Comments Off on Michael Morton Presents at EUROTOX 2018

ApconiX Welcomes George Buchanan

George joins ApconiX as a placement student for the month of August.  George graduated from the University of Newcastle last year after studying Biology.  He decided to take a year out before beginning a master’s degree in stem cell technology and regenerative medicine at the University of Nottingham in September. George was keen to gain [...]

By |2018-11-28T15:31:28+01:00July 31st, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes George Buchanan

ApconiX Welcomes Katie Cox

Katie joins ApconiX as a placement student for the month of July.  Katie, a third-year student from Sheffield University studying Biomedical Sciences hopes to carry on with her studies and complete a master’s degree at Sheffield after graduation. Eager to gain experience of a real-world laboratory, Katie took her tutor’s advice and applied.  Dr Stephen [...]

By |2018-07-31T10:46:01+01:00July 5th, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes Katie Cox

Proarrhythmia liability assessment and (CiPA): An industry survey on current practice.

Abstract Introduction The Safety Pharmacology Society (SPS) has conducted a survey of its membership to identify industry practices related to testing considered in the Comprehensive In vitroProarrhythmia Assay (CiPA). Methods Survey topics included nonclinical approaches to address proarrhythmia issues, conduct of in silico studies, in vitro ion channel testing methods used, drugs used as positive controls during the conduct of cardiac ion [...]

By |2018-11-22T11:58:28+01:00July 19th, 2018|Ion Channels, Publications|Comments Off on Proarrhythmia liability assessment and (CiPA): An industry survey on current practice.