The Reductionist Approach

The hERG assay has been a mainstay of safety screening in drug discovery for the last 2 decades. Aided by the development of high throughput automated technology, this important assay has brought unparalleled progress in our ability to design safer drugs without those properties that may lead to life-threatening cardiac arrhythmia. In a series of [...]

By |2019-07-24T14:41:23+01:00July 11th, 2019|Ion Channels|Comments Off on The Reductionist Approach

ApconiX Welcomes Priscilla Dumenu

ApconiX is delighted to welcome Priscilla Dumenu for a 2-week placement.  Priscilla will be working alongside Dr Michael Morton and Dr Karen Jones in the Ion Channel laboratory. Priscilla has just finished her second year studying Pharmacy at the University of Manchester.  The 5-year integrated master’s degree includes a placement year in a community or [...]

By |2019-06-28T18:12:07+01:00June 28th, 2019|Ion Channels, Careers|Comments Off on ApconiX Welcomes Priscilla Dumenu

Sophion’s Ion Channel Modulation Symposium

Dr Michael Morton will be attending Sophion’s Ion Channel Modulation Symposium, on the 19th to 20th of June 2019, at Clare College in Cambridge, UK. Sophion was founded almost twenty years ago by a group of passionate electrophysiologists and offers the some of the most flexible automated patch clamp systems on the market today. The [...]

By |2019-06-07T10:18:56+01:00June 12th, 2019|Ion Channels, Events|Comments Off on Sophion’s Ion Channel Modulation Symposium

ApconiX Joins the MDC’s Virtual R&D platform

ApconiX has joined the Medicines Discovery Catapult’s Virtual R&D platform.  This is a unique national network of consultants, private sector CROs, expert labs and public sector centres of excellence, providing medicines discovery expertise, services and virtual programme management. ApconiX specialises in ion channel biology, target safety assessments and in all aspects of nonclinical programme design [...]

By |2019-06-07T10:20:14+01:00June 6th, 2019|Ion Channels|Comments Off on ApconiX Joins the MDC’s Virtual R&D platform

ApconiX Welcomes Sushma Pabbineedi.

ApconiX is delighted to welcome Sushma Pabbineedi for a placement during May.  Sushma will be working alongside Dr Michael Morton and Dr Karen Jones in the ion channel laboratory. Sushma studied Biomedical Sciences and gained a bachelor’s degree from Manchester Metropolitan University.  She took a gap year working at the AQA examination board in Manchester [...]

By |2019-05-09T12:14:32+01:00May 9th, 2019|Ion Channels, Careers|Comments Off on ApconiX Welcomes Sushma Pabbineedi.

Identification of Selective Inhibitors of The Epithelial Sodium Channel 𝛿.

Victoria Miller, a PhD student from the Drug Discovery Centre at the University of Sussex recently spent a few months working in the ApconiX ion channel laboratory as a part of her research. Her PhD project titled “Identification of Potent and Selective Inhibitors of the Epithelial Sodium Channel 𝛿”, was supervised by Professors Martin Gosling [...]

By |2019-04-24T15:32:21+01:00May 1st, 2019|Ion Channels, Events|Comments Off on Identification of Selective Inhibitors of The Epithelial Sodium Channel 𝛿.

30th Symposium on Medicinal Chemistry in Eastern England

Dr Michael Morton will be attending the 30th Symposium on Medicinal Chemistry in Eastern England at Hatfield, United Kingdom on 2nd May 2019. This is a highly successful, long-standing, one-day annual meeting. To commemorate 30 years, the programme will focus on ‘Celebrating UK Drug Discovery’, highlighting success stories from large pharma, biotech and academia; and [...]

By |2019-04-24T14:56:18+01:00April 25th, 2019|Ion Channels, Events|Comments Off on 30th Symposium on Medicinal Chemistry in Eastern England

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Dr Michael Morton co-authored a paper recently published in the Journal of Cardiovascular Electrophysiology. The paper should serve as a reminder that ion channels which may not be the focus of regulatory guidance or the latest CiPA initiative, still play a critical role in cardiac function, and shouldn’t be forgotten. TASK‐1 (K2P3.1) is a member [...]

By |2019-04-18T10:09:25+01:00April 18th, 2019|Ion Channels, Publications|Comments Off on K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

SOT 58th Annual Meeting & ToxExpo – 2588: Talk by Dr Michael Morton of ApconiX

At the Society of Toxicology 58th Annual Meeting and ToxExpo from March 10th to 14th at the Baltimore Convention Center, Dr Michael Morton of ApconiX will be giving a talk as part of the workshop "Can we panelize seizure?".  On Wednesday March 13th 9:30am – 10:00am in the Convention Center Ballroom III.  An Innovations in Applied [...]

By |2019-03-06T11:22:16+01:00March 6th, 2019|Ion Channels, Events|Comments Off on SOT 58th Annual Meeting & ToxExpo – 2588: Talk by Dr Michael Morton of ApconiX

SOT 58th Annual Meeting & ToxExpo – 2072: Poster Presentation by Richard Printemps of PhysioStim

At the Society of Toxicology 58th Annual Meeting and ToxExpo from March 10th to 14th at the Baltimore Convention Center, poster presentation by Richard Printemps of PhysioStim on Tuesday March 12th 3:00pm - 4:30pm Poster Board P463 Convention Center Exhibition Hall.  Incorporating the CiPA Paradigm into an Integrated Cardiac Risk Assessment. Authors:  M. Morton1, R. Printemps2, M. [...]

By |2019-03-05T14:42:32+01:00March 5th, 2019|Ion Channels, Events|Comments Off on SOT 58th Annual Meeting & ToxExpo – 2072: Poster Presentation by Richard Printemps of PhysioStim