ApconiX Welcomes Bethany Russell

Bethany joins ApconiX as a placement student for part of September.  A second-year student, Bethany is studying Biomedical Sciences at Sheffield University.  Her degree is a four-year sandwich course, with a third-year placement in industry. Bethany was unsure if a career in a laboratory was for her and wanted to be clearer before making her [...]

By |2018-09-25T18:03:38+00:00October 4th, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes Bethany Russell

ApconiX is supporting PhysioStim at SPS

ApconiX and PhysioStim will be celebrating their first year of The European Centre of Excellence for preclinical cardiovascular electrophysiology at the Safety Pharmacology Society Annual Meeting in Washington this September.  ApconiX will be supporting PhysioStim as they exhibit at the Marriott Wardman Park Hotel on Stand 412 from the 30th of September to the 3rd [...]

By |2018-09-25T18:23:43+00:00September 26th, 2018|Ion Channels, Events|Comments Off on ApconiX is supporting PhysioStim at SPS

Michael Morton Presents at EUROTOX 2018

Dr Michael Morton will be speaking at EUROTOX this September in Belgium.  On Tuesday September 4th at 16:30 in Hall 100 Mike will address ‘Cardiac safety: current state of the art’ chaired by Dr Mark Holbrook of VAST Pharma solutions and Ester Lovsin-Barle from Lonza.  Mike will present ‘Ion channel profiling of stem cell-derived cardiomyocytes: [...]

By |2018-08-23T12:05:35+00:00August 29th, 2018|Ion Channels, Events|Comments Off on Michael Morton Presents at EUROTOX 2018

ApconiX Welcomes George Buchanan

George joins ApconiX as a placement student for the month of August.  George graduated from the University of Newcastle last year after studying Biology.  He decided to take a year out before beginning a master’s degree in stem cell technology and regenerative medicine at the University of Nottingham in September. George was keen to gain [...]

By |2018-07-31T13:02:03+00:00July 31st, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes George Buchanan

ApconiX Welcomes Katie Cox

Katie joins ApconiX as a placement student for the month of July.  Katie, a third-year student from Sheffield University studying Biomedical Sciences hopes to carry on with her studies and complete a master’s degree at Sheffield after graduation. Eager to gain experience of a real-world laboratory, Katie took her tutor’s advice and applied.  Dr Stephen [...]

By |2018-07-31T10:46:01+00:00July 5th, 2018|Ion Channels, Careers|Comments Off on ApconiX Welcomes Katie Cox

ApconiX Return Over 80% of hERG Screening Data to Clients Within One Week

Why is Time Critical to hERG Screening Data? ApconiX has worked hard to optimise our processes and is now returning over 80% of hERG screening data back to clients within one week of compound receipt.  This allows critical decisions to be made in medicinal chemistry on a full dataset of compound properties, avoiding mistakes and [...]

By |2018-07-19T16:25:00+00:00March 5th, 2018|Ion Channels|Comments Off on ApconiX Return Over 80% of hERG Screening Data to Clients Within One Week

ApconiX Welcomes Dr Karen Jones to The Team.

ApconiX is delighted to welcome Dr Karen Jones who joins us from AstraZeneca.  Karen, a talented electrophysiologist, will work with Dr Michael Morton to ensure the laboratory continues to provide an outstanding service as the demand for ion channel and cardiovascular safety screening increases. Karen graduated from the University of Liverpool with a degree in [...]

By |2018-07-11T14:36:29+00:00December 2nd, 2017|Ion Channels, Careers|Comments Off on ApconiX Welcomes Dr Karen Jones to The Team.

N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.

Abstract K+/Cl- cotransporter 2 (KCC2) is selectively expressed in the adult nervous system and allows neurons to maintain low intracellular Cl- levels. Thus, KCC2 activity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated by type A γ-aminobutyric acid (GABAA) receptors, which are Cl--permeable, ligand-gated ion channels. Consistent with this, deficits in the activity of KCC2 [...]

By |2018-07-05T13:46:47+00:00December 1st, 2017|Ion Channels, Publications|Comments Off on N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.

The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity.

Read more here: RA Cardarelli, K Jones, LI Pisella, HJ Wobst, LJ McWilliams, PM Sharpe, MP Burnham, DJ Baker, I Chudotvorova, J Guyot, L Silayeva, DH Morrow, N Dekker, S Zicha, PA Davies, J Holenz, ME Duggan, J Dunlop, RJ Mather, Q Wang, I Medina, NJ Brandon, TZ Deeb and SJ Moss. The small molecule CLP257 [...]

By |2018-07-11T14:46:53+00:00December 1st, 2017|Ion Channels, Publications|Comments Off on The small molecule CLP257 does not modify activity of the K+/Cl- co-transporter KCC2 but does potentiate GABA A receptor activity.

Learning from Failure

Cardiovascular toxicity often hinders success – are companies picking the wrong compounds? Prolific novelist and academic CS Lewis once said, “Failures are finger posts on the road to achievement.” (Given pharma’s drug failure rate, the road ahead must truly be paved in gold.) When it comes to drug safety failure, toxicity – especially to the [...]

By |2018-07-11T15:26:46+00:00November 2nd, 2017|Ion Channels, Press|Comments Off on Learning from Failure