An Integrated Approach for Early In Vitro Seizure Prediction Utilising hiPSC Neurons and Human Ion Channel Assays ApconiX are delighted with our recent publication in Toxicological Sciences where we presented our new data on our integrated approach to detecting seizure. After 3 years of research, we launched the seizure [...]
New Paper Published in Birth Defects Research Dr Jane Barber, Dr Claire Sadler and Dr Jane Stewart are among the authors of new paper published in Birth Defects Research. The Paper Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition Abstract Background MMV390048 is [...]
Phumzile Sikakana Celebrates a Few Firsts: First Paper as First Author and First Paper with ApconiX It’s great to have something to celebrate this year and ApconiX was delighted to hear Phumzile Sikakana had her first paper published with ApconiX. It was also Phum’s first, first author paper! A [...]
Seizure Toxicology Research Paper Published Introduction: Detection of neurotoxicity induced by prospective new therapies represents a major challenge due to the morphological and physiological complexity of the central nervous system (CNS). Characterised by uncontrolled electrical activity in the brain, seizure liability remains a significant cause of attrition in drug [...]
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity Abstract: Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed [...]
Innovative Models for In Vitro Detection of Seizure ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer [...]
Read the poster Dr Kim Rockley and Dr Michael Morton presented at ELRIG 2019 in Liverpool.
Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia Abstract: Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good [...]
Toxicological Sciences: From the Editor's Desk, Editor's Highlights One of the recent Editor's Highlights in Toxicological Sciences was a paper by Peters et al., on GI Barrier and Drug-induced Diarrhea, reviewed by Professor Ruth Roberts, an Associate Editor of Toxicological Sciences. As Ruth highlighted, attrition in drug discovery and [...]
K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall Dr Michael Morton co-authored a paper recently published in the Journal of Cardiovascular Electrophysiology. The paper should serve as a reminder that ion channels which may not be the focus of regulatory guidance or [...]
