Toxicological Sciences: From the Editor’s Desk, Editor’s Highlights

One of the recent Editor's Highlights in Toxicological Sciences was a paper by Peters et al., on GI Barrier and Drug-induced Diarrhea, reviewed by  Professor Ruth Roberts, an Associate Editor of Toxicological Sciences. As Ruth highlighted, attrition in drug discovery and development due to toxicity remains a major challenge. A plethora of preclinical in vitro models [...]

By |2019-04-24T14:58:09+01:00April 24th, 2019|Toxicology, Publications|Comments Off on Toxicological Sciences: From the Editor’s Desk, Editor’s Highlights

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Dr Michael Morton co-authored a paper recently published in the Journal of Cardiovascular Electrophysiology. The paper should serve as a reminder that ion channels which may not be the focus of regulatory guidance or the latest CiPA initiative, still play a critical role in cardiac function, and shouldn’t be forgotten. TASK‐1 (K2P3.1) is a member [...]

By |2019-04-18T10:09:25+01:00April 18th, 2019|Ion Channels, Publications|Comments Off on K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Toxicogenomics: A 2020 Vision

Together with the promotion of non-animal testing, in vitro toxicogenomics (TGx) may play a vital role in the next generation risk assessment paradigm. A strategic shift in risk assessment provides an unprecedented opportunity for repositioning TGx in the regulatory setting. As the emerging technique continues to impact the TGx field, novel genomic features such as [...]

By |2019-04-17T15:54:02+01:00April 17th, 2019|Toxicology, Publications|Comments Off on Toxicogenomics: A 2020 Vision

Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity

Abstract Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The purpose of this research was to use a novel planar sectioning technique to determine [...]

By |2019-01-30T12:25:18+01:00January 24th, 2019|Toxicology, Publications|Comments Off on Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity

Highlight Article for Experimental Biology and Medicine

“Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration”, co-authored by Abigail L Walker, Syed Z Imam and  Ruth A Roberts, has been selected as a highlight article for Experimental Biology and Medicine’s 243:13 issue. As a result of this designation it will be open access for 90 days. Click here to access Abstract The [...]

By |2018-12-06T13:53:13+01:00December 7th, 2018|Publications|Comments Off on Highlight Article for Experimental Biology and Medicine

Mother and Daughter on Front cover

Ruth Roberts and Emma Walker were featured on the front cover of Toxicology Research this month.  The mother and daughter’s review article, Collaboration and competition: ethics in toxicology hit the headlines in Volume 7. The front cover was painted by Emma, an accomplished artist as well as scientist.  Emma is currently studying for her Master’s [...]

By |2018-07-22T18:28:03+01:00July 22nd, 2018|Toxicology, Publications|Comments Off on Mother and Daughter on Front cover

Understanding drug targets: no such thing as bad news

Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated with proposed drug targets is a crucial element in understanding the unwanted side-effects that might stop a project in [...]

By |2018-10-01T17:36:10+01:00June 6th, 2018|Target Safety Assessments, Publications|Comments Off on Understanding drug targets: no such thing as bad news

Proarrhythmia liability assessment and (CiPA): An industry survey on current practice.

Abstract Introduction The Safety Pharmacology Society (SPS) has conducted a survey of its membership to identify industry practices related to testing considered in the Comprehensive In vitroProarrhythmia Assay (CiPA). Methods Survey topics included nonclinical approaches to address proarrhythmia issues, conduct of in silico studies, in vitro ion channel testing methods used, drugs used as positive controls during the conduct of cardiac ion [...]

By |2018-11-22T11:58:28+01:00July 19th, 2018|Ion Channels, Publications|Comments Off on Proarrhythmia liability assessment and (CiPA): An industry survey on current practice.

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Abstract: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on [...]

By |2018-06-27T16:11:13+01:00February 28th, 2018|Toxicology, Publications|Comments Off on Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Collaboration and Competition: Ethics in Toxicology

Two of the biggest ethical challenges in pharmaceutical toxicology are the use of animals in testing and the high safety-related attrition rates in new drug development.  Yet very little is invested in these two fields compared with investment in new efficacy models, new disease targets and new technologies.  How can this be addressed?  In this [...]

By |2018-05-30T16:00:00+01:00February 9th, 2018|Toxicology, Publications|Comments Off on Collaboration and Competition: Ethics in Toxicology