Understanding drug targets: no such thing as bad news

Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated with proposed drug targets is a crucial element in understanding the unwanted side-effects that might stop a project in [...]

By | 2018-06-13T16:08:37+00:00 June 6th, 2018|Toxicology, Publications|Comments Off on Understanding drug targets: no such thing as bad news

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Abstract: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on [...]

By | 2018-06-13T16:07:16+00:00 February 28th, 2018|Toxicology, Publications|Comments Off on Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Collaboration and Competition: Ethics in Toxicology

Two of the biggest ethical challenges in pharmaceutical toxicology are the use of animals in testing and the high safety-related attrition rates in new drug development.  Yet very little is invested in these two fields compared with investment in new efficacy models, new disease targets and new technologies.  How can this be addressed?  In this [...]

By | 2018-05-30T16:00:00+00:00 February 9th, 2018|Toxicology, Publications|Comments Off on Collaboration and Competition: Ethics in Toxicology

Who’s in the Top 10% of Articles in Toxicological Sciences?

Ruth Roberts is first author on one of Toxicological Sciences’ top 10% downloaded articles during the last 2 years. The paper, ‘Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward’ describes the challenges and opportunities in the development of biomarkers of neurotoxicity, a goal shared by scientists across academia, [...]

By | 2018-05-30T16:41:01+00:00 March 24th, 2017|Toxicology, Publications|Comments Off on Who’s in the Top 10% of Articles in Toxicological Sciences?

“Most Downloaded Article” award for Jane Stewart!

ApconiX Associate Jane Stewart is first author on a manuscript in the DIA peer-reviewed journal “Therapeutic Innovation and Regulatory Science” (TIRS)  that has received the DIA’s 2017 Author of the Year Award.  This annual award honours the author of the most accessed and downloaded article in TIRS.  The article ‘Birth Control in Clinical Trials: Industry [...]

By | 2018-06-06T15:49:06+00:00 February 15th, 2017|Toxicology, Publications|Comments Off on “Most Downloaded Article” award for Jane Stewart!

Publishing is the lifeblood of science – so what’s stopping you?

I love writing papers. I really enjoy the combination of creativity and logic required plus the sense of drawing a line under a piece of work.  It’s also great (usually!) to get the feedback of the scientific community both during and after the peer review process.  I rarely have anyone disagree with me on this, [...]

By | 2018-05-21T10:01:38+00:00 November 5th, 2015|Publications|Comments Off on Publishing is the lifeblood of science – so what’s stopping you?

Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel

Abstract: Background and Purpose: We aimed to characterize the pharmacology and electrophysiology of N-[3-(1H-benzimidazol-2-yl)-4-chloro-phenyl]pyridine-3-carboxamide (AZSMO-23), an activator of the human ether-a-go-go-related gene (hERG)-encoded K+ channel (Kv11.1). Experimental Approach: Automated electrophysiology was used to study the pharmacology of AZSMO-23 on wild-type (WT), Y652A, F656T or G628C/S631C hERG, and on other cardiac ion channels. Its mechanism of action [...]

By | 2018-06-20T16:06:22+00:00 June 20th, 2015|Ion Channels, Publications|Comments Off on Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel

Predicting changes in cardiac myocyte contractility during early drug discovery with in vitro assays

Abstract: Cardiovascular-related adverse drug effects are a major concern for the pharmaceutical industry. Activity of an investigational drug at the L-type calcium channel could manifest in a number of ways, including changes in cardiac contractility. The aim of this study was to define which of the two assay technologies - radioligand-binding or automated electrophysiology - [...]

By | 2018-06-20T16:43:00+00:00 September 20th, 2014|Ion Channels, Publications|Comments Off on Predicting changes in cardiac myocyte contractility during early drug discovery with in vitro assays

Preservation of cardiomyocytes from the adult heart

Abstract: Cardiomyocytes represent one of the most useful models to conduct cardiac research. A single adult heart yields millions of cardiomyocytes, but these cells do not survive for long after isolation. We aimed to determine whether inhibition of myosin II ATPase that is essential for muscle contraction may preserve fully differentiated adult cardiomyocytes. Using inhibitors [...]

By | 2018-06-20T16:53:12+00:00 November 20th, 2013|Ion Channels, Publications|Comments Off on Preservation of cardiomyocytes from the adult heart