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Acuity Target Safety Assessments (TSAs)

Our concise and customised target safety assessments will:

• Support timely and informed decision-making
• Maximise the use of your limited resources
• Boost confidence with a comprehensive search using the latest AI technology
• Include an optional annual update

Acuity Target Safety Assessments are created by project toxicologists, supported by artificial intelligence, to provide an understanding of target safety liabilities and a risk mitigation plan.

“The target safety evaluation was perfect.  Our toxicologist was very happy with the final document as was the project team.  Not only was the document great, it was delivered on time and the turn-around time for the edits was outstanding.  I have no doubt that we will be using your services in the future.”

James Murray, Toxicologist, Sanofi

“Working with ApconiX has been effortless! They have provided high quality target safety assessments with a focus on comprehensive interpretation of findings. The information provided has helped contribute to decisions on activities when moving early molecules forward. ApconiX constantly meets or exceeds timelines, while still providing flexibility to fit in last minute requests without impacting previously scheduled work. It has been a pleasure to work with Ruth and her team.”

Gilead Sciences


Your Acuity Target Safety Assessment:

  • Authored by project toxicologists familiar with discovery team dynamics
  • Individually tailored to the needs of each project
  • Focus on key risks to aid informed decision-making

Each TSA contains:

  • Executive summary of key information
  • Homology, expression, transgenic and mutation phenotypes
  • Key risks identified and categorised by tissue
  • Competitor information (public domain)
  • Mitigation plans with ranking of risks and potential next steps
  • Embedded PowerPoint ready for presentation

“ApconiX target reviews are of outstanding quality and obviously created by people with a thorough understanding of what is needed to help guide decisions.”

James S. MacDonald PhD, Synergy Partners R&D Solutions

If you would like to see an example of our Target Safety Assessments, please enter your details here.

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Associated Articles

The Value of Target Safety Assessments

Did you know that safety issues remain one of the main reason why drug projects fail?   Multiple publications over recent years have continued to highlight non-clinical safety/toxicity as the most frequent reason for project failure [...]

Target Safety Assessments: Strategies and Resources

Target Safety Assessment: Strategies and Resources, Chapter 12 of Drug Safety Evaluation Methods in Molecular Biology (vol 1641), was written by Dr Richard J Brennan, a Scientific Advisor at Sanofi in the United States. The [...]

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