Dr Claire Sadler PhD. Claire is an experienced project toxicologist and former Director of Discovery Safety within AstraZeneca. Claire specialises in early project safety assessment, identifying and mitigating risks from target identification through to early clinical trials. She has worked across multiple therapy areas including oncology, infection, immune and cardiovascular, and on many drug platforms including small molecules, proteins and novel platforms. She has been directly involved in bringing many candidate drugs to clinical trial, submitted through different territory regulatory agencies. She has a proven track record in problem solving and in investigational cellular and molecular toxicology. She is expert in designing and implementing bespoke safety packages and in developing strategies to drive compound design and selection.