ApconiX Opens a New Office in Sweden

ApconiX is excited to announce the opening of our new office in Sweden.  The subsidiary ApconiX AB will be located at AstraZeneca’s BioVentureHub in Mölndal, Gothenburg. ApconiX was formed by Dr Richard Knight, Dr Michael Morton and Professor Ruth Roberts in 2015 and is based at Alderley Park in Cheshire, U.K.   The co-founders have established [...]

By |2019-02-07T12:13:15+00:00February 7th, 2019|Ion Channels, Target Safety Assessments, Toxicology, Events|Comments Off on ApconiX Opens a New Office in Sweden

Professor Ruth Roberts Hosts ATS Meeting

Professor Ruth Roberts was elected President of the Academy of Toxicology Sciences in June 2018 and holds the position until June 2019.  She will be hosting the ATS Annual Business Meeting and Reception at SOT on Tuesday, March 12 where she will be presenting Dr William Slikker, Jr. with the 2019 Mildred Christian Award at [...]

By |2019-02-06T11:25:46+00:00February 6th, 2019|Toxicology, Events|Comments Off on Professor Ruth Roberts Hosts ATS Meeting

ApconiX Welcomes Dr Steffen Ernst

ApconiX is delighted to welcome Dr Steffen Ernst to our team, as the company begins its international expansion with the formation of its Swedish subsidiary, ApconiX AB. Steffen has worked in preclinical and clinical safety for over 20 years with Hoechst-Schering, Boehringer-Ingelheim, AstraZeneca, Pfizer and Ipsen, holding various pre-clinical and clinical positions of ever-increasing responsibility [...]

By |2019-02-07T16:37:23+00:00February 6th, 2019|Toxicology, Careers|Comments Off on ApconiX Welcomes Dr Steffen Ernst

ApconiX Welcomes Dr Bjorn Dahl

ApconiX is delighted to welcome Dr Björn Dahl to the team, who joins our new Swedish office at AstraZeneca’s BioVentureHub in Mölndal, Gothenburg. Björn is a highly respected and experienced toxicologist, having been the co-chair of the European Federation Pharmaceutical Industry Association (EFPIA) Preclinical Development Expert Working Group and served as the EFPIA topic lead [...]

By |2019-02-07T16:37:46+00:00February 6th, 2019|Toxicology, Careers|Comments Off on ApconiX Welcomes Dr Bjorn Dahl

Professor Ruth Roberts Becomes an Honorary Fellow of the British Toxicology Society

ApconiX are delighted to learn that the BTS Executive Committee has elected Professor Ruth Roberts as Honorary Fellow of the British Toxicology Society (hon FBTS) in recognition of her outstanding contribution to the science and profession of Toxicology, including to the BTS. Ruth commented “It’s such an honour to be recognised in this way by [...]

By |2019-01-30T15:27:43+00:00January 31st, 2019|Toxicology, Events, Uncategorised|Comments Off on Professor Ruth Roberts Becomes an Honorary Fellow of the British Toxicology Society

Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity

Abstract Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of photoreceptors) has been associated with CDK inhibitors, including the pan-CDK inhibitor AG-012896. The purpose of this research was to use a novel planar sectioning technique to determine [...]

By |2019-01-30T12:25:18+00:00January 24th, 2019|Toxicology, Publications|Comments Off on Differential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity

Collaboration and competition: ethics in toxicology

What are our attitudes to research resourcing, publication and the peer review system?  The British Toxicology Society (BTS) is conducting a survey to establish attitudes of toxicologists to key questions such as ‘I believe collaboration to be important in driving toxicology research in the UK’ and ‘I believe the current system of peer review for [...]

By |2018-11-28T15:34:59+00:00September 27th, 2018|Toxicology|Comments Off on Collaboration and competition: ethics in toxicology

Choosing the right non-clinical CRO

Non-clinical contract research organisations (CROs) are an integral part of modern drug development. For any novel agent, delivery of GLP toxicity data to support clinical trials is a crucial step that requires a professional organisation with dedicated management, infrastructure and a broad array of technical and scientific skills. In selecting a CRO, the sponsor typically [...]

By |2018-09-12T14:07:14+00:00September 19th, 2018|Toxicology, Press|Comments Off on Choosing the right non-clinical CRO

Paul Duffy Presents at EUROTOX 2018

Dr Paul Duffy will be speaking at EUROTOX this September. On Monday 3rd of September at 16:30 in the SILVER Hall Paul will address “Old drugs in new guises: the toxicology of repurposing” chaired and introduced by Ruth Roberts and Dr Miranda Cornet from UCB in Belgium.  Paul will present case studies to illustrate the [...]

By |2018-08-23T12:05:58+00:00August 22nd, 2018|Toxicology, Events|Comments Off on Paul Duffy Presents at EUROTOX 2018

ApconiX at EUROTOX 2018

Dr Michael Morton, Professor Ruth Roberts, Dr Richard Knight and Dr Paul Duffy will be attending EUROTOX this September in Brussels. The theme for 2018 is “Toxicology Out of the Box” and reflects the federation’s willingness and enthusiasm to offer an innovative, forward-looking and imaginative scientific programme.  ‘"The theme for EUROTOX aligns perfectly with our [...]

By |2018-08-15T09:24:31+00:00August 15th, 2018|Toxicology, Events|Comments Off on ApconiX at EUROTOX 2018