Understanding drug targets: no such thing as bad news

Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated with proposed drug targets is a crucial element in understanding the unwanted side-effects that might stop a project in [...]

By | 2018-06-13T16:08:37+00:00 June 6th, 2018|Toxicology, Publications|Comments Off on Understanding drug targets: no such thing as bad news

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Abstract: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on [...]

By | 2018-06-13T16:07:16+00:00 February 28th, 2018|Toxicology, Publications|Comments Off on Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

Redx Pharma Announces First Patient Dosed in Phase 1/2a

Redx Pharma has commenced a Phase I study for a novel cancer treatment at The Christie in Manchester. The compound, RXC004, is a novel, oral, potent small molecule Porcupine inhibitor, and targets the Wnt pathway that is implicated in the maintenance of cancer stem cells. ApconiX were proud to work with our Redx colleagues in [...]

By | 2018-05-30T15:50:20+00:00 February 13th, 2018|Toxicology|Comments Off on Redx Pharma Announces First Patient Dosed in Phase 1/2a

Magic Mushrooms May Treat Depression

This recent article in the Sunday Times discusses how an extract of magic mushrooms may be able to make significant improvements in the treatment of severe depression. We were delighted to bring ApconiX's drug project toxicologist expertise to the team of experts working with COMPASS Pathways to find a safe, efficient and effective route into [...]

By | 2018-05-30T15:54:28+00:00 February 13th, 2018|Toxicology|Comments Off on Magic Mushrooms May Treat Depression

Collaboration and Competition: Ethics in Toxicology

Two of the biggest ethical challenges in pharmaceutical toxicology are the use of animals in testing and the high safety-related attrition rates in new drug development.  Yet very little is invested in these two fields compared with investment in new efficacy models, new disease targets and new technologies.  How can this be addressed?  In this [...]

By | 2018-05-30T16:00:00+00:00 February 9th, 2018|Toxicology, Publications|Comments Off on Collaboration and Competition: Ethics in Toxicology

Guy Healing to join the UK Register of Toxicologists Panel!

Guy Healing was recently selected from many applications to join the panel of the UK register of toxicologists www.toxreg.org.uk.  The UKRT was created in 1993 in response to the need for international harmonization and mutual recognition of toxicologists and is sponsored by The Royal Society of Biology and the British Toxicology Society. By identifying professional [...]

By | 2018-05-30T16:22:35+00:00 November 2nd, 2017|Toxicology|Comments Off on Guy Healing to join the UK Register of Toxicologists Panel!

Who’s in the Top 10% of Articles in Toxicological Sciences?

Ruth Roberts is first author on one of Toxicological Sciences’ top 10% downloaded articles during the last 2 years. The paper, ‘Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward’ describes the challenges and opportunities in the development of biomarkers of neurotoxicity, a goal shared by scientists across academia, [...]

By | 2018-05-30T16:41:01+00:00 March 24th, 2017|Toxicology, Publications|Comments Off on Who’s in the Top 10% of Articles in Toxicological Sciences?

“Most Downloaded Article” award for Jane Stewart!

ApconiX Associate Jane Stewart is first author on a manuscript in the DIA peer-reviewed journal “Therapeutic Innovation and Regulatory Science” (TIRS)  that has received the DIA’s 2017 Author of the Year Award.  This annual award honours the author of the most accessed and downloaded article in TIRS.  The article ‘Birth Control in Clinical Trials: Industry [...]

By | 2018-06-06T15:49:06+00:00 February 15th, 2017|Toxicology, Publications|Comments Off on “Most Downloaded Article” award for Jane Stewart!

How much effort is the Pharmaceutical Industry making to replace animal testing?

From my own first-hand experience, the pharmaceutical industry has invested and continues to invest massively in replacing animal testing.  Indeed, there are many publications describing these efforts and many of these have driven changes in practice.  But despite this, it would seem that much of this effort has gone unnoticed in the outside world.    In [...]

By | 2018-05-21T10:01:41+00:00 November 5th, 2015|Toxicology|Comments Off on How much effort is the Pharmaceutical Industry making to replace animal testing?