Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, chemistry and patient.  For example, T: what are the safety implications of modulating the target?  C: What are the likely [...]

By |2019-08-07T15:17:44+01:00August 7th, 2019|Toxicology|Comments Off on Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

Dr Kimberly Rockley Wins EUROTOX Fellowship Grant

ApconiX was delighted to hear that Dr Kimberly Rockley had received a EUROTOX Fellowship Grant to attend the Gordon Research Seminar and Conference in the USA this August. The Cellular and Molecular Mechanisms of Toxicity Conference “Integration of Emerging Technologies in Mechanistic and Translational Toxicology” runs from the 11th to the 16th of August and [...]

By |2019-07-24T14:43:16+01:00July 10th, 2019|Toxicology, Events|Comments Off on Dr Kimberly Rockley Wins EUROTOX Fellowship Grant

ApconiX Welcomes Dr Kimberly Rockley.

ApconiX is delighted to welcome Dr Kimberly Rockley.  Kim has a strong research background in oncology and will work with the team of experts in nonclinical safety and toxicology at ApconiX. Kim studied Biomedical Science and gained her bachelor’s degree and her master’s degree in Cancer Pharmacology at the University of Bradford, graduating with distinction. [...]

By |2019-06-11T10:31:11+01:00June 11th, 2019|Toxicology, Careers|Comments Off on ApconiX Welcomes Dr Kimberly Rockley.

ApconiX Meet with the Servier Nonclinical Safety Team in Paris

Professor Ruth Roberts and Dr Paul Duffy recently spent some time with the Servier nonclinical safety team in Paris, hosted by Dr Nancy Claude, Director of Non-Clinical Safety at Servier and Patrick Genissel, Director Centre of Excellence Research & Biopharmacy, R & D VP. The discussions focused on science-led strategies to nonclinical development of new [...]

By |2019-05-28T10:18:11+01:00May 26th, 2019|Toxicology, Events|Comments Off on ApconiX Meet with the Servier Nonclinical Safety Team in Paris

Practical Application of Toxicology in Drug Development

Professor Ruth Roberts, Co-founder and Director of ApconiX will be joining Rob Wallis and other eminent scientists in delivering training at the highly acclaimed course Practical Application of Toxicology in Drug Development.  The course, co-organised by the British Toxicology Society and the American College of Toxicology will be held at The Møller Centre, Churchill College, [...]

By |2019-05-08T10:47:02+01:00May 9th, 2019|Toxicology, Events|Comments Off on Practical Application of Toxicology in Drug Development

Professor Ruth Roberts Joins Bio Integrates Panel

Professor Ruth Roberts, Co-founder and Director of ApconiX will join Professor Paul Stott, Chief Executive Officer of Seda Pharmaceutical Development Services, Dr Steve McConchie, Chief Executive Officer of Aptus Clinical and Dr Matt Cooper, Business Development & Marketing Director of National Institute for Health Research to discuss “Collaborating Across the Value Chain to Translate Great [...]

By |2019-05-08T10:04:15+01:00May 8th, 2019|Toxicology, Events|Comments Off on Professor Ruth Roberts Joins Bio Integrates Panel

Toxicological Sciences: From the Editor’s Desk, Editor’s Highlights

One of the recent Editor's Highlights in Toxicological Sciences was a paper by Peters et al., on GI Barrier and Drug-induced Diarrhea, reviewed by  Professor Ruth Roberts, an Associate Editor of Toxicological Sciences. As Ruth highlighted, attrition in drug discovery and development due to toxicity remains a major challenge. A plethora of preclinical in vitro models [...]

By |2019-04-24T14:58:09+01:00April 24th, 2019|Toxicology, Publications|Comments Off on Toxicological Sciences: From the Editor’s Desk, Editor’s Highlights

British Toxicology Society Congress a Great Success

Dr Richard Knight, Dr Guy Healing, Professor Ruth Roberts, Phumzile Sikakana and Dr Karin Burnett thoroughly enjoyed the British Society of Toxicology Congress this week at Robinson College, University of Cambridge. Highlights of the meeting included a great opening keynote from Dr Stefan Platz (AstraZeneca) who shared his vision for the use of AI in [...]

By |2019-04-18T10:14:42+01:00April 18th, 2019|Toxicology, Events|Comments Off on British Toxicology Society Congress a Great Success

Toxicogenomics: A 2020 Vision

Together with the promotion of non-animal testing, in vitro toxicogenomics (TGx) may play a vital role in the next generation risk assessment paradigm. A strategic shift in risk assessment provides an unprecedented opportunity for repositioning TGx in the regulatory setting. As the emerging technique continues to impact the TGx field, novel genomic features such as [...]

By |2019-04-17T15:54:02+01:00April 17th, 2019|Toxicology, Publications|Comments Off on Toxicogenomics: A 2020 Vision

ApconiX Attends British Toxicology Society Congress – “Celebrating 40 years of the BTS”.

British Toxicology Society (BTS) and the UK Environmental Mutagen Society Annual Congress “Celebrating 40 years of the BTS" will be held at Robinson College, University of Cambridge between 15th -17th of April. Professor Ruth Roberts, Dr Richard Knight, Dr Guy Healing and Phumzile Sikakana will all be attending.  Ruth will be presented with an Honorary Fellowship [...]

By |2019-04-14T16:01:01+01:00April 14th, 2019|Toxicology, Events|Comments Off on ApconiX Attends British Toxicology Society Congress – “Celebrating 40 years of the BTS”.