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Impact of Target Expression on the Adverse Event Profile of Antibody-Drug Conjugates (ADCs): Implications for Target Safety Assessments

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An integrated approach for early in vitro seizure prediction utilising human-derived induced pluripotent stem cells and human ion channel assays

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Improved Sustainability Through the Use of Assay Ready Cells to Support Ion Channel Screening

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Development of a human derived induced pluripotent stem cell neuronal assay for early in vitro detection of seizure liability

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What are the common predicted toxicities from target safety assessments?

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Initial testing of an ion channel panel for early in vitro detection of seizure liability

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A combined in vitro approach for early seizure prediction utilising human derived induced pluripotent stem cells and human ion channel assays

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Comparison of cross-species homologous drug targets to support Target safety Assessments

Are stem cell cardiomyocytes a viable cellular color

Are stem-cell cardiomyocytes a viable cellular reagent for automated patch-clamp?

Collaboration Competition and Publication in Toxicology Views of the BTS color

Collaboration, Competition and Publication in Toxicology Views of the BTS

Electrophysiological Analysis of Seroquels Activity in Sodium Ion Channels CiPA ion channels and hiPSC neuronal cellscolor

Electrophysiological Analysis of Seroquel’s Activity in Sodium Ion Channels CiPAion channels and hiPSC neuronal cells

Evaluation of the Toxicological Risk of targeting FRS Phenylalanyl tRNA Synthetase in the Treatment of Malaria color

Evaluation of the Toxicological Risk of targeting FRS (Phenylalanyl-tRNA Synthetase) in the Treatment of Malaria

Incorporating the CiPA paradigm into an integrated cardiac risk assessment color

Incorporating the CiPA paradigm into an integrated cardiac risk assessment

Sodium channel selectivity of three anti epileptic drugscolor

Sodium channel selectivity of three anti-epileptic drugs

Target safety assessments and their role in de risking drug discovery NaV1.7 as an

Target safety assessments and their role in de-risking drug discovery NaV1.7 as an example

The CiPA Profile of Two Adenosine Uptake Inhibitors dilazep and dipyridamole

The CiPA Profile of Two Adenosine Uptake Inhibitors dilazep and dipyridamole

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SOT WTPS Poster 2021

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SOT WTPS to Poster Commentary 2021