Professor Ruth Roberts is guest speaker at the 22nd Annual John Doull Toxicology Symposium. This event is taking place on the 29th of September at 9am CDT. The Symposium is part of the University of Kansas, School of Medicine, Pharmacology, Toxicology & Therapeutics' series of seminars. Attendance is limited but if you are interested please [...]
Join Dr Richard Knight, Co-founder and Director of ApconiX, Dr Peter Warn consultant at Magic Bullet Consulting, and Aleksander Danilovski, Chief Scientific Officer & Senior Vice President, Global R&D and Regulatory Affairs at Xelia at the 4th AMR Conference as they discuss the "Top 10 Mistakes in Antibacterial Development". In view of the continuing uncertain situation [...]
Join Professor Ruth Roberts for the next science webinar in the Alderley Park Science Seminar Series: Science-Driven Design of the Preclinical Strategy: Case by Case Tuesday, 11 August 2020 12:00 pm to 1:00 pm Ruth will present lessons learned from >20 years’ experience in the pharmaceutical industry focusing on attrition, prediction and the challenges posed by nonclinical [...]
Professor Ruth Roberts, Dr Claire Sadler and Dr Leigh Ann Burns Nass present Target Safety Assessments: Knowledge is Power webinar in a SOT 2020 Exhibitor Hosted Session. Membership of SOT is not required. Registration for the webinar is free.
The meeting that ApconiX is co-organising the British Toxicology Society “Science-led Strategies for Success in Discovery and Development Toxicology” is being rearranged for a date later in 2020 - watch this space for updates! Sponsored by Lonza and AstraZeneca and co-organised by ApconiX, GlaxoSmithKline, Sygnature Discovery and Alderley Park, the meeting is focused on safety [...]
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity
Abstract: Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed with known DILI severity and toxicity. We augmented the DILIrank data set [annotated using US Food and Drug Administration (FDA) drug [...]
Team ApconiX had a fabulous time at their Christmas party - secret Santa brought tears of laughter and sorrow and the odd gasp! A few team members went incognito. Wishing everyone a lovely holiday and the very best for the coming year. Looking forward to a new decade and new challenges. See you in 2020!
Professor Ruth Roberts, Co-Founder and Director of ApconiX will be speaking at the American Association of Pharmaceutical Scientists (AAPS) on Monday 4th November at 9:00am in a session entitled "Next Generation Technologies in Preclinical Development” chaired by Dr Shraddha Thakkar from the US FDA. Ruth’s talk is entitled “Science-Driven Design of the Preclinical Package: Case [...]
A thorough understanding of potential target-related effects is crucial to making the right choices in drug discovery. Experienced project toxicologists extract and interpret data from mouse knockouts, human gene mutations and known effects of modulators to determine the potential consequences of target inhibition or activation in each organ system. Target Safety Assessments are pivotal in [...]
Dr Kimberly Rockley and Professor Ruth Roberts had a fabulous time at the Gordon Research Seminar (GRS) and Conference (GRC) earlier this month. GRCs provide an international forum for the presentation and discussion of cutting-edge research in science; GRSs are organised by and for young investigators and take place alongside the GRC. L to [...]