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About Ruth Roberts

Professor Ruth A Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath Director and Cofounder, ApconiX, UK and Chair and Director of Drug Discovery, University of Birmingham, UK Ruth is chair of drug discovery at Birmingham University, UK and Cofounder of ApconiX, an integrated toxicology and ion channel company that brings together a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development experience. Previously, Ruth was Global Head of Regulatory Safety at AstraZeneca and Director of Toxicology for Aventis. Ruth is an established science professional bringing rigorous expert thinking to toxicology, drug discovery and drug development. With >140 publications in peer reviewed journals, she is focused on reducing attrition attributable to safety and toxicity. A former president of the British Toxicology Society, former president of EUROTOX, former secretary to SOT and president elect of the Academy of Toxicological Sciences, Ruth was the recipient of the SOT Achievement award in 2002, the EUROTOX Bo Holmstedt Award in 2009 and the SOT Founders award in 2018 for outstanding leadership in toxicology.

Acuity Target Safety Assessments: Knowledge is Power

A thorough understanding of potential target-related effects is crucial to making the right choices in drug discovery.  Experienced project toxicologists extract and interpret data from mouse knockouts, human gene mutations and known effects of modulators to determine the potential consequences of target inhibition or activation in each organ system. Target Safety Assessments are pivotal in [...]

By |2019-10-01T14:04:36+01:00October 1st, 2019|Target Safety Assessments|Comments Off on Acuity Target Safety Assessments: Knowledge is Power

Dr Kimberly Rockley Presents at the 2019 Gordon Research Conference

Dr Kimberly Rockley and Professor Ruth Roberts had a fabulous time at the Gordon Research Seminar (GRS) and Conference (GRC) earlier this month.  GRCs provide an international forum for the presentation and discussion of cutting-edge research in science; GRSs are organised by and for young investigators and take place alongside the GRC. L to [...]

By |2019-09-04T14:03:05+01:00September 5th, 2019|Events|Comments Off on Dr Kimberly Rockley Presents at the 2019 Gordon Research Conference

Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, chemistry and patient.  For example, T: what are the safety implications of modulating the target?  C: What are the likely [...]

By |2019-08-07T15:17:44+01:00August 7th, 2019|Toxicology|Comments Off on Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia

Abstract: Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in [...]

By |2019-08-07T10:14:32+01:00August 6th, 2019|Publications|Comments Off on Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia

How Alderley Park Grew into an Innovation Hub

A great piece in the Financial Times this week “How Alderley Park Grew into an Innovation Hub” which highlights the success of Alderley Park following AstraZeneca’s announced departure 5 years ago.  Ned Wakeman talks about his team’s continued support of the start-up companies and Dr Chris Doherty explains the vision of the site that will [...]

By |2019-08-01T09:03:51+01:00July 31st, 2019|Press|Comments Off on How Alderley Park Grew into an Innovation Hub

Dr Kimberly Rockley Wins EUROTOX Fellowship Grant

ApconiX was delighted to hear that Dr Kimberly Rockley had received a EUROTOX Fellowship Grant to attend the Gordon Research Seminar and Conference in the USA this August. The Cellular and Molecular Mechanisms of Toxicity Conference “Integration of Emerging Technologies in Mechanistic and Translational Toxicology” runs from the 11th to the 16th of August and [...]

By |2019-07-24T14:43:16+01:00July 10th, 2019|Toxicology, Events|Comments Off on Dr Kimberly Rockley Wins EUROTOX Fellowship Grant

ApconiX Welcomes Dr Kimberly Rockley.

ApconiX is delighted to welcome Dr Kimberly Rockley.  Kim has a strong research background in oncology and will work with the team of experts in nonclinical safety and toxicology at ApconiX. Kim studied Biomedical Science and gained her bachelor’s degree and her master’s degree in Cancer Pharmacology at the University of Bradford, graduating with distinction. [...]

By |2019-06-11T10:31:11+01:00June 11th, 2019|Toxicology, Careers|Comments Off on ApconiX Welcomes Dr Kimberly Rockley.

ApconiX Meet with the Servier Nonclinical Safety Team in Paris

Professor Ruth Roberts and Dr Paul Duffy recently spent some time with the Servier nonclinical safety team in Paris, hosted by Dr Nancy Claude, Director of Non-Clinical Safety at Servier and Patrick Genissel, Director Centre of Excellence Research & Biopharmacy, R & D VP. The discussions focused on science-led strategies to nonclinical development of new [...]

By |2019-05-28T10:18:11+01:00May 26th, 2019|Toxicology, Events|Comments Off on ApconiX Meet with the Servier Nonclinical Safety Team in Paris

ApconiX Welcomes Dr Russell Huby to the Team.

ApconiX is delighted to welcome Dr Russell Huby to the team.  Russell joins the team of experts in nonclinical safety toxicology at ApconiX and will be primarily working in the area of target safety assessments. Russell graduated from the University of Oxford with a bachelor’s degree in biochemistry before going on to gain a PhD [...]

By |2019-05-09T12:14:19+01:00May 14th, 2019|Target Safety Assessments, Careers|Comments Off on ApconiX Welcomes Dr Russell Huby to the Team.

Practical Application of Toxicology in Drug Development

Professor Ruth Roberts, Co-founder and Director of ApconiX will be joining Rob Wallis and other eminent scientists in delivering training at the highly acclaimed course Practical Application of Toxicology in Drug Development.  The course, co-organised by the British Toxicology Society and the American College of Toxicology will be held at The Møller Centre, Churchill College, [...]

By |2019-05-08T10:47:02+01:00May 9th, 2019|Toxicology, Events|Comments Off on Practical Application of Toxicology in Drug Development