About Ruth Roberts

Professor Ruth A Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath Director and Cofounder, ApconiX, UK and Chair and Director of Drug Discovery, University of Birmingham, UK Ruth is chair of drug discovery at Birmingham University, UK and Cofounder of ApconiX, an integrated toxicology and ion channel company that brings together a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development experience. Previously, Ruth was Global Head of Regulatory Safety at AstraZeneca and Director of Toxicology for Aventis. Ruth is an established science professional bringing rigorous expert thinking to toxicology, drug discovery and drug development. With >140 publications in peer reviewed journals, she is focused on reducing attrition attributable to safety and toxicity. A former president of the British Toxicology Society, former president of EUROTOX, former secretary to SOT and president elect of the Academy of Toxicological Sciences, Ruth was the recipient of the SOT Achievement award in 2002, the EUROTOX Bo Holmstedt Award in 2009 and the SOT Founders award in 2018 for outstanding leadership in toxicology.

ApconiX Welcomes Dr Karin Burnett to The Team.

ApconiX is delighted to welcome Dr Karin Burnett, an experienced project toxicologist with a broad knowledge of toxicology and chemical risk assessment in the pharmaceutical industry.  Karin will join the team of experts in nonclinical safety toxicology at ApconiX, who cover all major safety disciplines and are committed to advancing the science of drug safety. Karin [...]

By |2018-11-28T16:37:14+00:00December 12th, 2018|Target Safety Assessments, Careers|Comments Off on ApconiX Welcomes Dr Karin Burnett to The Team.

Highlight Article for Experimental Biology and Medicine

“Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration”, co-authored by Abigail L Walker, Syed Z Imam and  Ruth A Roberts, has been selected as a highlight article for Experimental Biology and Medicine’s 243:13 issue. As a result of this designation it will be open access for 90 days. Click here to access Abstract The [...]

By |2018-12-06T13:53:13+00:00December 7th, 2018|Publications|Comments Off on Highlight Article for Experimental Biology and Medicine

ApconiX Welcomes Phumzile Sikakana to The Team.

ApconiX is delighted to welcome Phumzile Sikakana who joins us straight from University.  Phum, an enthusiastic new masters graduate will work with our team of experienced scientists on a variety of projects, including target safety reviews and in the ion channel screening laboratory, helping our clients make better decisions on drug safety. Phum studied Biomedical [...]

By |2018-11-30T09:11:38+00:00December 5th, 2018|Target Safety Assessments, Careers|Comments Off on ApconiX Welcomes Phumzile Sikakana to The Team.

Insider Breakfast Golden Triangle Breakfast Event

Professor Ruth Roberts was thrilled to be invited to speak at Business Insider’s recent Golden Triangle Breakfast Event at Alderley Park in the Northwest.  The new golden triangle is part of a vision to take the Cheshire Science Corridor and create a golden triangle in the Northwest to rival the original golden triangle of Oxford, [...]

By |2018-11-28T16:41:51+00:00November 29th, 2018|Events|Comments Off on Insider Breakfast Golden Triangle Breakfast Event

Making safety a part of drug design

The Global Antibiotic R&D Partnership (GARDP) will host a live webinar with ApconiX's Dr Claire Sadler on ''Making safety a part of drug design" on 13th November 16.00-17.30 GMT.  Claire is an expert discovery project toxicologist specialising in early project safety assessment and risk mitigation.  In this webinar, she discusses the toxicological challenges and pitfalls [...]

By |2018-11-08T13:12:06+00:00November 2nd, 2018|Events|Comments Off on Making safety a part of drug design

Target Safety Reports: What’s in a Name?

Irrespective of what we call them, target safety reports form a key part of risk assessment and risk mitigation plans in drug discovery and development. Why is that?  Well, target-related toxicity accounts for >50% of all drug project failures (Cook et al., 2014) so it’s vital to understand the potential unintended consequences of target modulation.  [...]

By |2018-10-12T14:15:50+00:00October 12th, 2018|Target Safety Assessments|Comments Off on Target Safety Reports: What’s in a Name?

Collaboration and competition: ethics in toxicology

What are our attitudes to research resourcing, publication and the peer review system?  The British Toxicology Society (BTS) is conducting a survey to establish attitudes of toxicologists to key questions such as ‘I believe collaboration to be important in driving toxicology research in the UK’ and ‘I believe the current system of peer review for [...]

By |2018-11-28T15:34:59+00:00September 27th, 2018|Toxicology|Comments Off on Collaboration and competition: ethics in toxicology

ApconiX at EUROTOX 2018

Dr Michael Morton, Professor Ruth Roberts, Dr Richard Knight and Dr Paul Duffy will be attending EUROTOX this September in Brussels. The theme for 2018 is “Toxicology Out of the Box” and reflects the federation’s willingness and enthusiasm to offer an innovative, forward-looking and imaginative scientific programme.  ‘"The theme for EUROTOX aligns perfectly with our [...]

By |2018-08-15T09:24:31+00:00August 15th, 2018|Toxicology, Events|Comments Off on ApconiX at EUROTOX 2018

Mother and Daughter on Front cover

Ruth Roberts and Emma Walker were featured on the front cover of Toxicology Research this month.  The mother and daughter’s review article, Collaboration and competition: ethics in toxicology hit the headlines in Volume 7. The front cover was painted by Emma, an accomplished artist as well as scientist.  Emma is currently studying for her Master’s [...]

By |2018-07-22T18:28:03+00:00July 22nd, 2018|Toxicology, Publications|Comments Off on Mother and Daughter on Front cover

Project Toxicologist

The Role:  We are looking for a project toxicologist with at least 5 years of experience supporting diverse drug discovery and development projects.  Experience of small molecules, biologics and new modalities in any therapy area are all of interest.  You will have the experience and gravitas to work alone with clients in a project environment, [...]

By |2018-09-12T16:14:16+00:00July 2nd, 2018|Job Vacancies|Comments Off on Project Toxicologist