About Ruth Roberts

Professor Ruth A Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath Director and Cofounder, ApconiX, UK and Chair and Director of Drug Discovery, University of Birmingham, UK Ruth is chair of drug discovery at Birmingham University, UK and Cofounder of ApconiX, an integrated toxicology and ion channel company that brings together a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development experience. Previously, Ruth was Global Head of Regulatory Safety at AstraZeneca and Director of Toxicology for Aventis. Ruth is an established science professional bringing rigorous expert thinking to toxicology, drug discovery and drug development. With >140 publications in peer reviewed journals, she is focused on reducing attrition attributable to safety and toxicity. A former president of the British Toxicology Society, former president of EUROTOX, former secretary to SOT and president elect of the Academy of Toxicological Sciences, Ruth was the recipient of the SOT Achievement award in 2002, the EUROTOX Bo Holmstedt Award in 2009 and the SOT Founders award in 2018 for outstanding leadership in toxicology.

Target Safety Reports: What’s in a Name?

Irrespective of what we call them, target safety reports form a key part of risk assessment and risk mitigation plans in drug discovery and development. Why is that?  Well, target-related toxicity accounts for >50% of all drug project failures (Cook et al., 2014) so it’s vital to understand the potential unintended consequences of target modulation.  [...]

By |2018-10-12T14:15:50+00:00October 12th, 2018|Target Safety Assessments|Comments Off on Target Safety Reports: What’s in a Name?

Collaboration and competition: ethics in toxicology

What are our attitudes to research resourcing, publication and the peer review system?  The British Toxicology Society (BTS) is conducting a survey to establish attitudes of toxicologists to key questions such as ‘I believe collaboration to be important in driving toxicology research in the UK’ and ‘I believe the current system of peer review for [...]

By |2018-09-27T18:18:55+00:00September 27th, 2018|Toxicology|Comments Off on Collaboration and competition: ethics in toxicology

ApconiX at EUROTOX 2018

Dr Michael Morton, Professor Ruth Roberts, Dr Richard Knight and Dr Paul Duffy will be attending EUROTOX this September in Brussels. The theme for 2018 is “Toxicology Out of the Box” and reflects the federation’s willingness and enthusiasm to offer an innovative, forward-looking and imaginative scientific programme.  ‘"The theme for EUROTOX aligns perfectly with our [...]

By |2018-08-15T09:24:31+00:00August 15th, 2018|Toxicology, Events|Comments Off on ApconiX at EUROTOX 2018

Mother and Daughter on Front cover

Ruth Roberts and Emma Walker were featured on the front cover of Toxicology Research this month.  The mother and daughter’s review article, Collaboration and competition: ethics in toxicology hit the headlines in Volume 7. The front cover was painted by Emma, an accomplished artist as well as scientist.  Emma is currently studying for her Master’s [...]

By |2018-07-22T18:28:03+00:00July 22nd, 2018|Toxicology, Publications|Comments Off on Mother and Daughter on Front cover

Project Toxicologist

The Role:  We are looking for a project toxicologist with at least 5 years of experience supporting diverse drug discovery and development projects.  Experience of small molecules, biologics and new modalities in any therapy area are all of interest.  You will have the experience and gravitas to work alone with clients in a project environment, [...]

By |2018-09-12T16:14:16+00:00July 2nd, 2018|Job Vacancies|Comments Off on Project Toxicologist

Target Safety Biologist/Market Intelligence Lead

The Role: We are looking for a research-minded scientist to join our team of target safety biologists.  The team create target safety assessments (TSAs) to help our growing list of clients make crucial decisions on progressing drug projects.  Each TSA involves compiling and interpreting relevant literature on a particular drug target to provide an expert [...]

By |2018-09-12T16:14:16+00:00July 2nd, 2018|Job Vacancies|Comments Off on Target Safety Biologist/Market Intelligence Lead

Understanding drug targets: no such thing as bad news

Abstract: How can small-to-medium pharma and biotech companies enhance the chances of running a successful drug project and maximise the return on a limited number of assets? Having a full appreciation of the safety risks associated with proposed drug targets is a crucial element in understanding the unwanted side-effects that might stop a project in [...]

By |2018-10-01T17:36:10+00:00June 6th, 2018|Target Safety Assessments, Publications|Comments Off on Understanding drug targets: no such thing as bad news

Ruth wins the 2018 SOT Founders Award!

The official photographs are out to show that it was all smiles in San Antonio earlier this year when I received the 2018 Society of Toxicology (SOT) founders award.  I was proud to be presented with the  plaque by my good friend and colleague, Leigh Ann Burns Naas.  Dr Burns Naas is SOT President as [...]

By |2018-05-30T13:46:49+00:00May 24th, 2018|Events|Comments Off on Ruth wins the 2018 SOT Founders Award!

RSB Presidents Dinner

Ruth Roberts (ApconiX) and Emma Walker (Kings College London) attended the Royal Society of Biology President's Dinner May 2nd 2018 where they chatted with Stephen Benn about the great work he does as Vice-President of the Parliamentary and Scientific Committee and for the Society as their Director of Parliamentary Affairs. Professor Dame Julia Goodfellow succeeded [...]

By |2018-07-22T19:09:38+00:00May 9th, 2018|Events|Comments Off on RSB Presidents Dinner

ApconiX Welcomes Dr Jane Barber to The Team

ApconiX is delighted to welcome Dr Jane Barber who joins us from AstraZeneca.  Jane, a dedicated drug discovery research scientist will work with the team of experts in nonclinical safety toxicology at ApconiX. Jane graduated from the University of Keele with a degree in Biology and Classical studies.  After researching Molecular Parasitology and Vector Biology, [...]

By |2018-08-23T10:56:48+00:00May 1st, 2018|Target Safety Assessments, Events|Comments Off on ApconiX Welcomes Dr Jane Barber to The Team