About Ruth Roberts

Professor Ruth A Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath Director and Cofounder, ApconiX, UK and Chair and Director of Drug Discovery, University of Birmingham, UK Ruth is chair of drug discovery at Birmingham University, UK and Cofounder of ApconiX, an integrated toxicology and ion channel company that brings together a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development experience. Previously, Ruth was Global Head of Regulatory Safety at AstraZeneca and Director of Toxicology for Aventis. Ruth is an established science professional bringing rigorous expert thinking to toxicology, drug discovery and drug development. With >140 publications in peer reviewed journals, she is focused on reducing attrition attributable to safety and toxicity. A former president of the British Toxicology Society, former president of EUROTOX, former secretary to SOT and president elect of the Academy of Toxicological Sciences, Ruth was the recipient of the SOT Achievement award in 2002, the EUROTOX Bo Holmstedt Award in 2009 and the SOT Founders award in 2018 for outstanding leadership in toxicology.

Professor Ruth Roberts Hosts ATS Meeting

Professor Ruth Roberts was elected President of the Academy of Toxicology Sciences in June 2018 and holds the position until June 2019.  She will be hosting the ATS Annual Business Meeting and Reception at SOT on Tuesday, March 12 where she will be presenting Dr William Slikker, Jr. with the 2019 Mildred Christian Award at [...]

By |2019-02-06T11:25:46+00:00February 6th, 2019|Toxicology, Events|Comments Off on Professor Ruth Roberts Hosts ATS Meeting

Phumzile Sikakana Graduates

Phum graduated from the University of Sheffield this month with a master’s degree following research into “The role of the phosphoinositide (PI) 5-kinase PIKfyve in phagosome maturation and killing, using the amoeba and model phagocyte Dictyostelium discoideum”. It was brilliant to hear Phum had been awarded a distinction. Everyone at ApconiX says, “Well Done!”

By |2019-01-16T13:58:58+00:00January 22nd, 2019|Events|Comments Off on Phumzile Sikakana Graduates

ApconiX Awards Prize for Best Toxicology Project

ApconiX is very happy to sponsor the best MSc Toxicology Project prize at the University of Birmingham. This year’s winner was Christopher Cox.  Chris was investigating the mechanisms of toxicity of ferro-nucleobases developed at Birmingham by James Tucker (Professor of Supramolecular Chemistry) in pancreatic ductal adenoma cell lines. (J. Med. Chem., 2014, 57 (13), pp [...]

By |2019-02-06T11:35:21+00:00January 17th, 2019|Events|Comments Off on ApconiX Awards Prize for Best Toxicology Project

Professor Ruth Roberts on SOT Ballot

ApconiX is happy to announce that Professor Ruth Roberts is on the SOT ballot for the position of Vice President-Elect.  As Secretary to SOT, Ruth was the first non-US based Council member and now hopes to be the first non-US based President! ‘It’s a great honour to be asked to stand for election to lead [...]

By |2019-02-06T11:28:11+00:00January 9th, 2019|Events|Comments Off on Professor Ruth Roberts on SOT Ballot

ApconiX Welcomes Dr Karin Burnett to The Team.

ApconiX is delighted to welcome Dr Karin Burnett, an experienced project toxicologist with a broad knowledge of toxicology and chemical risk assessment in the pharmaceutical industry.  Karin will join the team of experts in nonclinical safety toxicology at ApconiX, who cover all major safety disciplines and are committed to advancing the science of drug safety. Karin [...]

By |2018-11-28T16:37:14+00:00December 12th, 2018|Target Safety Assessments, Careers|Comments Off on ApconiX Welcomes Dr Karin Burnett to The Team.

Highlight Article for Experimental Biology and Medicine

“Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration”, co-authored by Abigail L Walker, Syed Z Imam and  Ruth A Roberts, has been selected as a highlight article for Experimental Biology and Medicine’s 243:13 issue. As a result of this designation it will be open access for 90 days. Click here to access Abstract The [...]

By |2018-12-06T13:53:13+00:00December 7th, 2018|Publications|Comments Off on Highlight Article for Experimental Biology and Medicine

ApconiX Welcomes Phumzile Sikakana to The Team.

ApconiX is delighted to welcome Phumzile Sikakana who joins us straight from University.  Phum, an enthusiastic new masters graduate will work with our team of experienced scientists on a variety of projects, including target safety reviews and in the ion channel screening laboratory, helping our clients make better decisions on drug safety. Phum studied Biomedical [...]

By |2019-01-16T14:12:29+00:00December 5th, 2018|Target Safety Assessments, Careers|Comments Off on ApconiX Welcomes Phumzile Sikakana to The Team.

Insider Breakfast Golden Triangle Breakfast Event

Professor Ruth Roberts was thrilled to be invited to speak at Business Insider’s recent Golden Triangle Breakfast Event at Alderley Park in the Northwest.  The new golden triangle is part of a vision to take the Cheshire Science Corridor and create a golden triangle in the Northwest to rival the original golden triangle of Oxford, [...]

By |2018-11-28T16:41:51+00:00November 29th, 2018|Events|Comments Off on Insider Breakfast Golden Triangle Breakfast Event

Making safety a part of drug design

The Global Antibiotic R&D Partnership (GARDP) will host a live webinar with ApconiX's Dr Claire Sadler on ''Making safety a part of drug design" on 13th November 16.00-17.30 GMT.  Claire is an expert discovery project toxicologist specialising in early project safety assessment and risk mitigation.  In this webinar, she discusses the toxicological challenges and pitfalls [...]

By |2018-11-08T13:12:06+00:00November 2nd, 2018|Events|Comments Off on Making safety a part of drug design

Target Safety Reports: What’s in a Name?

Irrespective of what we call them, target safety reports form a key part of risk assessment and risk mitigation plans in drug discovery and development. Why is that?  Well, target-related toxicity accounts for >50% of all drug project failures (Cook et al., 2014) so it’s vital to understand the potential unintended consequences of target modulation.  [...]

By |2018-10-12T14:15:50+00:00October 12th, 2018|Target Safety Assessments|Comments Off on Target Safety Reports: What’s in a Name?