Ruth Roberts

About Ruth Roberts

Professor Ruth A Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath. A co-founder of ApconiX, Ruth has 25 years of experience in leading roles in drug safety within large pharma. Ruth is also Chair and Director of Drug Discovery at The University of Birmingham, UK and was previously Global Head of Regulatory Safety at AstraZeneca. With over 140 publications in peer-reviewed journals, she is former president of the British Toxicology Society, former president of EUROTOX, former secretary to SOT and President of the Academy of Toxicological Sciences. Ruth was the recipient of the SOT Achievement award in 2002, the EUROTOX Bo Holmstedt Award in 2009 and the SOT Founders award in 2018 for outstanding leadership in toxicology. Ruth is an established science professional bringing rigorous expert thinking to toxicology, drug discovery and drug development.

Phumzile Sikakana Celebrates a Few Firsts: First Paper as First Author and First Paper with ApconiX

It’s great to have something to celebrate this year and ApconiX was delighted to hear Phumzile Sikakana had her first paper published with ApconiX.  It was also Phum’s first, first author paper! A Decade of Toxicological Trends: What the Papers Say: download the free access paper here: Phumzile Sikakana, Ruth A Roberts, A decade of [...]

By |2020-11-25T17:16:08+00:00November 25th, 2020|Publications|Comments Off on Phumzile Sikakana Celebrates a Few Firsts: First Paper as First Author and First Paper with ApconiX

ApconiX is Exhibiting at the ACT 2020 Annual Meeting

Professor Ruth Roberts and Dr Laurence Bishop is attending the 41st Annual Meeting of the American College of Toxicology "Bringing Austin to You" from the 12th to the 19th of November 2020.  ApconiX is also exhibiting at this virtual event from the 16th to the 18th of November and Ruth and Laurence look forward to [...]

By |2020-11-23T15:02:56+00:00November 11th, 2020|Events|Comments Off on ApconiX is Exhibiting at the ACT 2020 Annual Meeting

ApconiX is Recruiting a Target Safety Assessment Discipline Lead

ApconiX is a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development expertise. We were formed in 2015 by three scientists with the drive and ambition to create a world-renowned company.  We are now looking to grow our team of experts by the addition of talented and dedicated life [...]

By |2020-11-23T15:05:10+00:00November 4th, 2020|Careers|Comments Off on ApconiX is Recruiting a Target Safety Assessment Discipline Lead

Improve Drug Project Success by Understanding Drug Target Safety

Join Professor Ruth Roberts, Director and Co-founder, ApconiX Ltd, Dr Claire Sadler, Project Toxicologist, ApconiX and Dr Leigh Ann Burns Nass, President/Owner, Magnolia Toxicology Consulting, LLC in a live webinar on Thursday, October 1, 2020 at 11am EDT (4pm BST/UK) In this free webinar, hosted by XTALKS, the speakers will explore data access and interpretation using [...]

By |2020-10-12T17:32:20+01:00September 24th, 2020|Uncategorised|Comments Off on Improve Drug Project Success by Understanding Drug Target Safety

22nd Annual John Doull Symposium

Professor Ruth Roberts is guest speaker at the 22nd Annual John Doull Toxicology Symposium.  This event is taking place on the 29th of September at 9am CDT.  The Symposium is part of the University of Kansas, School of Medicine, Pharmacology, Toxicology & Therapeutics' series of seminars. Attendance is limited but if you are interested please [...]

By |2020-10-21T15:17:26+01:00September 17th, 2020|Events|Comments Off on 22nd Annual John Doull Symposium

Join Dr Richard Knight at the Digital AMR Conference

Join Dr Richard Knight, Co-founder and Director of ApconiX, Dr Peter Warn consultant at Magic Bullet Consulting, and Aleksander Danilovski, Chief Scientific Officer & Senior Vice President, Global R&D and Regulatory Affairs at Xelia at the 4th AMR Conference as they discuss the "Top 10 Mistakes in Antibacterial Development". In view of the continuing uncertain situation [...]

By |2020-11-23T15:07:56+00:00August 19th, 2020|Events|Comments Off on Join Dr Richard Knight at the Digital AMR Conference

Science-Driven Design of the Preclinical Strategy: Case by Case

Join Professor Ruth Roberts for the next science webinar in the Alderley Park Science Seminar Series: Science-Driven Design of the Preclinical Strategy: Case by Case Tuesday, 11 August 2020 12:00 pm to 1:00 pm Ruth will present lessons learned from >20 years’ experience in the pharmaceutical industry focusing on attrition, prediction and the challenges posed by nonclinical [...]

By |2020-11-23T15:08:49+00:00August 5th, 2020|Events|Comments Off on Science-Driven Design of the Preclinical Strategy: Case by Case

Discover the Power of Target Safety Assessments in a SOT EHS Webinar

Professor Ruth Roberts, Dr Claire Sadler and Dr Leigh Ann Burns Nass present Target Safety Assessments: Knowledge is Power webinar in a SOT 2020 Exhibitor Hosted Session.  Membership of SOT is not required.  Registration for the webinar is free.  

By |2020-07-02T15:47:19+01:00July 2nd, 2020|Events|Comments Off on Discover the Power of Target Safety Assessments in a SOT EHS Webinar

ApconiX Co-organises British Toxicology Society Meeting

The meeting that ApconiX is co-organising the British Toxicology Society  “Science-led Strategies for Success in Discovery and Development Toxicology” is being rearranged for a date later in 2020 - watch this space for updates! Sponsored by Lonza and AstraZeneca and co-organised by ApconiX, GlaxoSmithKline, Sygnature Discovery and Alderley Park,  the meeting is focused on safety [...]

By |2020-11-23T15:12:23+00:00March 8th, 2020|Events|Comments Off on ApconiX Co-organises British Toxicology Society Meeting

Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity

Abstract: Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed with known DILI severity and toxicity. We augmented the DILIrank data set [annotated using US Food and Drug Administration (FDA) drug [...]

By |2020-03-11T16:00:36+00:00January 16th, 2020|Publications|Comments Off on Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity