Target Safety Assessment: Strategies and Resources, Chapter 12 of Drug Safety Evaluation Methods in Molecular Biology (vol 1641), was written by Dr Richard J Brennan, a Scientific Advisor at Sanofi in the United States.
The chapter presents a summary of the information types and sources that should be investigated and approaches that can be taken to generate an early assessment of potential safety liabilities of proposed drug targets. Target safety assessments, sometimes called target safety evaluations, reviews or reports are an invaluable resource throughout drug discovery and development.
In the summary, the author commented:
“In our experience, the availability of a target safety assessment and a plan of action based on its findings has been successful in providing timely data for predicted liabilities that has had a direct impact on project progression decisions.”
Here at ApconiX, we have a team of experienced drug discovery toxicologists who conduct bespoke target safety assessments designed to meet your needs, with our strong focus on risk mitigation and actionable recommendations.
Abstract
An in-depth evaluation of target safety is an invaluable resource throughout drug discovery and development. The goal of a target safety evaluation is to identify potential unintended adverse consequences of target modulation and to propose a risk evaluation and mitigation strategy to shepherd compounds through the discovery and development pipeline, to confirm and characterize unavoidable on-target toxicities in a timely manner to assist in early program advancement decisions, and to anticipate, monitor, and manage potential clinical adverse events. The role of an experienced discovery toxicologist in synthesizing the available information into an actionable set of recommendations for a safety evaluation strategy is critical to its successful application in early discovery programs. This chapter presents a summary of some of the information types and sources that should be investigated, and approaches that can be taken to generate an early assessment of potential safety liabilities.
