Here’s what ion channels the Pharma industry routinely screens (Authier et al., 2017):
NaV1.5 is cardiac sodium channel, CaV1.2 is cardiac “L-type” calcium channel, kvLQT1 is cardiac lks current
ApconiX also offers a more comprehensive assessment of cardiac liability. Additional sodium channel and calcium channel assays are available routinely that give further insight. In addition, there are other cardiac ion channel assays we can deploy on a case-by-case basis to suit your needs, e.g. hERG trafficking, cardiac “T-type” calcium channel or Kv1.5. You will gain a deeper understanding of the potential for effects on cardiac safety to refine your decision-making and deliver an optimal (de-risked) clinical candidate.
We can also offer more advanced models of cardiac safety, such as Purkinje fibre, cardiac contractility and Langendorf models.
It is a regulatory requirement that an assessment of hERG inhibition should be made by manual patch-clamp to Good Laboratory Practise (GLP) standards. GLP-hERG is provided through our expert partner, PhysioStim.
Given over 300 years of combined expertise in drug discovery and safety, ApconiX is uniquely positioned to work with your project team to
interpret your data in the context of your drug discovery program.