ApconiX Upgrade to a QPatch ll 48 Automated Patch Clamp to Meet Demand ApconiX, the integrated toxicology and ion channel company, has acquired a QPatch ll 48 with temperature control to meet the increasing demand from their clients. As the first CRO to invest in QPatch II in the [...]
ApconiX Is Recruiting an Expert Electrophysiologist ApconiX is a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development expertise. We were formed in 2015 by three scientists with the drive and ambition to create a world-renowned company. We are now looking to grow our [...]
Dr Michael Morton is Attending the 31st Symposium on Medicinal Chemistry in Eastern England Dr Michael Morton is attending the 31st symposium on Medicinal Chemistry in Eastern England on Thursday 26th of November. ApconiX is also exhibiting at the virtual event. Mike commented, “RSC events are always a great [...]
The Evolving Role of Ion Channels in Shaping Successful Drug Discovery - Live Webinar For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery. Join Dr Michael Morton, Director and Co-founder of ApconiX in a live webinar on [...]
Dr Michael Morton is Attending Safety Pharmacology Society Dr Michael Morton will be attending the annual Safety Pharmacology Society Meeting being held virtually this year between 14th and 17th of September. Mike will be presenting Poster 030: Electrophysiological analysis of Seroquel’s activity in sodium ion channels, CiPA ion channels [...]
ApconiX Welcomes Dr Selvan Bavan ApconiX welcomes Dr Selvan Bavan, who joins us to carry out ion channel research using manual patch-clamp while learning more about using automated patch-clamp by working with Dr Michael Morton and Dr Karen Jones. Selvan commented, “Conventional manual patch-clamp is regarded as a ‘gold [...]
Cardiac Safety in Drug Development: CiPA In the second of a three-part series looking at cardiac safety testing in early drug discovery, Dr Michael Morton of ApconiX considers the CiPA initiative and how its integrated approach sits alongside existing strategies. What is the CiPA initiative and what does it [...]
ApconiX Welcomes Charlotte North ApconiX welcomes Charlotte North to the team. Charlotte graduated from Sheffield University in July with a degree in Biomedical Sciences and is working in the ApconiX Ion Channel Laboratory as an industry placement student this month. Charlotte has been spending her time, since graduating, exploring [...]
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
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