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About Michael Morton

Dr Michael Morton PhD. A co-founder of ApconiX, Mike is an expert electrophysiologist and ion channel biologist with extensive experience gained in academia and industry. Mike’s career has spanned pure research, ion channel assay development and large-scale screening of all manner of ligand- and voltage-gated ion channels. Mike learned his craft as a postdoctoral fellow first at Leeds (with Malcolm Hunter) then at Yale (with Fred Sigworth) before joining the global ion channel initiative at AstraZeneca where his skills were applied to drug projects. Mike has a serious passion for ion channels and enjoys working with collaborators and clients alike to ensure the highest quality data are used to support better decision-making.

ApconiX Welcomes Dr Selvan Bavan

ApconiX welcomes Dr Selvan Bavan, who joins us to carry out ion channel research using manual patch-clamp while learning more about using automated patch-clamp by working with Dr Michael Morton and Dr Karen Jones. Selvan commented, “Conventional manual patch-clamp is regarded as a ‘gold standard’ technique to record ion channel currents, but this technique has [...]

By |2020-04-22T10:37:18+01:00April 15th, 2020|Careers|Comments Off on ApconiX Welcomes Dr Selvan Bavan

Cardiac Safety in Drug Development: CiPA

In the second of a three-part series looking at cardiac safety testing in early drug discovery, Dr Michael Morton of ApconiX considers the CiPA initiative and how its integrated approach sits alongside existing strategies. What is the CiPA initiative and what does it mean for drug discovery? In the first blog, we outlined the background [...]

By |2020-02-19T13:03:20+00:00February 19th, 2020|Ion Channels|Comments Off on Cardiac Safety in Drug Development: CiPA

ApconiX Welcomes Charlotte North

ApconiX welcomes Charlotte North to the team.  Charlotte graduated from Sheffield University in July with a degree in Biomedical Sciences and is working in the ApconiX Ion Channel Laboratory as an industry placement student this month. Charlotte has been spending her time, since graduating, exploring the many opportunities the pharmaceutical industry can offer.  She is [...]

By |2020-02-13T16:12:43+00:00February 13th, 2020|Careers|Comments Off on ApconiX Welcomes Charlotte North

My Brush with Greatness

It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this time, Neher and Sakmann had recruited a Post Doc called [...]

By |2020-01-30T14:21:05+00:00January 16th, 2020|Ion Channels|Comments Off on My Brush with Greatness

An Ascorbate-Induced Increase in Sodium Current

The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles.  Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, ascorbic acid. The Science Firstly, it was important to examine any potential [...]

By |2020-01-30T14:52:24+00:00January 16th, 2020|Ion Channels|Comments Off on An Ascorbate-Induced Increase in Sodium Current

Dr Kimberly Rockley’s First Six Months at ApconiX

Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Here she reflects on her first 6 months with the company. “Having gained a background in cancer biology, toxicology and in vitro research techniques from my Master’s degree and PhD research I was [...]

By |2020-01-22T13:34:12+00:00January 16th, 2020|Careers|Comments Off on Dr Kimberly Rockley’s First Six Months at ApconiX

Dr Michael Morton Attends Genedata Biopharma Open Forum

Dr Michael Morton is attending “Accelerating Biopharma R&D with Innovative Biopharma Data Management and Analysis” at the Swiss Embassy in London today.  The event was organised by Genedata. Speakers include Dr Peter Whitfield, Senior Scientific Data Analyst at GSK, Chris Wilson, Senior Scientist at Crescendo Biologics Limited, Alex Stowell, Lead Biologist at CRUK Manchester Institute [...]

By |2019-12-04T14:11:05+00:00December 4th, 2019|Events|Comments Off on Dr Michael Morton Attends Genedata Biopharma Open Forum

ApconiX Is Presenting a Poster at ELRIG 2019

ApconiX is delighted to be presenting a poster at ELRIG 2019 titled “Sodium channel selectivity of two anti-epileptic drugs.”  The poster includes research started by our placement student Priscilla Dumenu. Dr Michael Morton, Dr Richard Knight, Dr Kimberly Rockley, Phumzile Sikakana and Olivia Turner are all attending the conference. “I am really looking forward to [...]

By |2019-10-30T15:08:26+00:00October 30th, 2019|Events|Comments Off on ApconiX Is Presenting a Poster at ELRIG 2019

Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting

Dr Michael Morton, Director and Co-Founder will be speaking at the 10th  Nanion User Meeting on Thursday 17th of October, "Two Years of Experience and Learning with Patchliner".  The User Meeting is being held from Wednesday 17th to Thursday 18th of October at Nanion’s headquarters in Munich. Founded in 2002, Nanion has grown to be [...]

By |2019-10-13T17:50:37+01:00October 13th, 2019|Ion Channels, Events|Comments Off on Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting

Is Expert Interpretation as Good as Complex Computational Modelling?

Come and complete the questionnaire Dr Hitesh Mistry has developed to investigate whether expert interpretation of data is as good as complex computational modelling at the Safety Pharmacology Society Annual Meeting at Barcelona this week.  ApconiX will have copies of the questionnaire on their stand number 307. Dr Hitesh Mistry is a computational modelling expert [...]

By |2019-09-23T19:32:19+01:00September 23rd, 2019|Events|Comments Off on Is Expert Interpretation as Good as Complex Computational Modelling?