Translational Safety from
Small Molecules to New Modalities
We are delighted to celebrate the fourth year of our Drug Safety Forum, providing a platform for nonclinical and clinical communities to engage with current safety science and offer a future perspective. We focus on new theoretical and experimental approaches to translational safety science.
The central themes of the forum are two-fold; what more can we achieve and what new models can we access that helps us to better understand what will happen in the clinic.
As there is a limited number of places for this symposium. Registration requires a passcode.
If you would like to attend and haven’t yet received a passcode, please contact us at drug.safety.forum@apconix.com
Programme:
The format includes talks, discussion and debates, ensuring the patient remains at the centre of our thinking.
| Time | Title | Speaker |
|---|---|---|
| 9:00 – 9:45 | Arrival and Registration | |
| 9:45 – 10:00 | Introduction | Dr Richard Knight |
| Opening Keynote | ||
| 10:00 – 10:30 | The UK “Replacing Animals in Science” Strategy: One Year On; Reactions and Opportunities | Dr Anthony Holmes (NC3Rs) |
| 10:30 – 10:45 | Questions & Discussion | |
| 10:45 – 11:05 | Bringing Safer Medicines to Patients using AI: Real World Case Studies | Dr Layla Hosseini-Gerami (Ignota Labs) |
| 11:05 – 11:15 | Questions & Discussion | |
| 11:15 – 11:35 | Predicting on and off target Safety Across Modalities: a Key Early Derisking Approach | Dr James Sidaway (ApconiX) |
| 11:35 – 11:45 | Questions & Discussion | |
| 11:45 – 12:05 | Single-Cell Mechanistic AI for Toxicology | Shawn Owens (Deepcyte Bio) |
| 12:05 – 12:15 | Questions & Discussion | |
| 12:15 – 13:15 | Lunch | |
| 13:15 – 13:45 | Four 3 minute pitches – some latest science from ApconiX | |
| 13:45 – 13:55 | Questions & Discussion | |
| 14:00 – 14:20 | Reimagining Safety Assessment with New Approach Methodologies | Rhiannon David (AstraZeneca) |
| 14:20 – 14:30 | Questions & Discussion | |
| 14:30 – 15:20 | Artificial Intelligence and Machine Learning Applications to Safety Science for Early Derisking | Dr James McDonagh (ApconiX) |
| 15:20 – 15:30 | Questions & Discussion | |
| 15:30 – 15:50 | A UK Regulatory Perspective on Emerging Approaches to Nonclinical Safety | Kathryn Costelloe (MHRA) |
| 15:50 – 16:00 | Questions & Discussion | |
| 16:00 | Panel Discussion: What do you think we will be highlighting at this meeting in 5 years’ time? |
Chair: Professor Ruth Roberts |
| 17:00 | Close | |