Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study. Abstract: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as [...]
Did you know that safety issues remain one of the main reasons why drug projects fail? Multiple publications over recent years have continued to highlight non-clinical safety/toxicity as the most frequent reason for project failure in drug development. For example, in a study of 605 projects from GSK, AstraZeneca, Ely Lilly and Pfizer, nonclinical toxicology [...]
Looking forward to seeing everyone at SOT 2018. Ruth Roberts will be the proud recipient of the 2018 SOT Founders Award at the Awards Ceremony on Sunday evening and Ruth and Claire Sadler will be presenting in the session on Elevator Pitches on Tuesday afternoon. Come and say Hi to Ruth, Richard Knight, Mike [...]
Redx Pharma has commenced a Phase I study for a novel cancer treatment at The Christie in Manchester. The compound, RXC004, is a novel, oral, potent small molecule Porcupine inhibitor, and targets the Wnt pathway that is implicated in the maintenance of cancer stem cells. ApconiX were proud to work with our Redx colleagues in [...]
This recent article in the Sunday Times discusses how an extract of magic mushrooms may be able to make significant improvements in the treatment of severe depression. We were delighted to bring ApconiX's drug project toxicologist expertise to the team of experts working with COMPASS Pathways to find a safe, efficient and effective route into [...]
Two of the biggest ethical challenges in pharmaceutical toxicology are the use of animals in testing and the high safety-related attrition rates in new drug development. Yet very little is invested in these two fields compared with investment in new efficacy models, new disease targets and new technologies. How can this be addressed? In this [...]
Ruth A. Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath, ApconiX, Alderley Edge, United Kingdom, is the recipient of the Society of Toxicology (SOT) 2018 Founders Award for 'outstanding leadership in fostering the role of toxicological sciences in safety decision-making'. Dr. Roberts is chair and director of drug discovery at the University of Birmingham, United [...]
ApconiX Newsletter January 2018 Please click on the title to hear all about people, places and progress. Best regards Ruth, Mike and Richard
Professor Ruth Roberts – co-founder and director of nonclinical safety company, ApconiX based at Alderley Park, Cheshire – is the first non-US-based scientist to receive a prestigious international award for professionals specialising in drug and chemical safety. She is only the tenth person to receive the US-based Society of Toxicology (SOT) Founders Award, presented for “outstanding leadership in fostering the role [...]
We were delighted to be named 2017 Start Up Start-Up of the Year by BioNow, the northern England bio-medical and life sciences membership organisation. It's been an outstanding year for ApconiX with more than 60 clients across the UK, US and Europe including Pfizer, UCB and Gilead, as well as bio-techs, start-ups and university spin-outs. [...]
