Redx Pharma has commenced a Phase I study for a novel cancer treatment at The Christie in Manchester. The compound, RXC004, is a novel, oral, potent small molecule Porcupine inhibitor, and targets the Wnt pathway that is implicated in the maintenance of cancer stem cells. ApconiX were proud to work with our Redx colleagues in [...]
This recent article in the Sunday Times discusses how an extract of magic mushrooms may be able to make significant improvements in the treatment of severe depression. We were delighted to bring ApconiX's drug project toxicologist expertise to the team of experts working with COMPASS Pathways to find a safe, efficient and effective route into [...]
Two of the biggest ethical challenges in pharmaceutical toxicology are the use of animals in testing and the high safety-related attrition rates in new drug development. Yet very little is invested in these two fields compared with investment in new efficacy models, new disease targets and new technologies. How can this be addressed? In this [...]
Ruth A. Roberts, PhD, ATS, FBTS, ERT, FRSB, FRCPath, ApconiX, Alderley Edge, United Kingdom, is the recipient of the Society of Toxicology (SOT) 2018 Founders Award for 'outstanding leadership in fostering the role of toxicological sciences in safety decision-making'. Dr. Roberts is chair and director of drug discovery at the University of Birmingham, United [...]
ApconiX Newsletter January 2018 Please click on the title to hear all about people, places and progress. Best regards Ruth, Mike and Richard
Professor Ruth Roberts – co-founder and director of nonclinical safety company, ApconiX based at Alderley Park, Cheshire – is the first non-US-based scientist to receive a prestigious international award for professionals specialising in drug and chemical safety. She is only the tenth person to receive the US-based Society of Toxicology (SOT) Founders Award, presented for “outstanding leadership in fostering the role [...]
We were delighted to be named 2017 Start Up Start-Up of the Year by BioNow, the northern England bio-medical and life sciences membership organisation. It's been an outstanding year for ApconiX with more than 60 clients across the UK, US and Europe including Pfizer, UCB and Gilead, as well as bio-techs, start-ups and university spin-outs. [...]
Guy Healing was recently selected from many applicants to join the panel of the UK register of toxicologists. The UKRT was created in 1993 in response to the need for international harmonization and mutual recognition of toxicologists and is sponsored by The Royal Society of Biology and the British Toxicology Society. By identifying professional toxicologists [...]
Jane Stewart recently lectured on Reprotoxicology within the Non Clinical Development module of the TOPRA MSc course. As the professional membership organisation for individuals working in healthcare regulatory affairs, TOPRA works with its members internationally to enable and promote excellence across the healthcare regulatory profession. This course, for healthcare regulatory professionals, was attended by students [...]
This poster, presented at the Gordon Research Conference in August 2017, concluded that: Target safety assessments: Provide expert assessment and interpretation of literature and available databases and are invaluable in identifying and avoiding target-related risks Inform target selection and/or prioritisation early in discovery Should contain the level of detail appropriate to the project stage Should [...]
