Seizure Toxicology Research Paper Published Introduction: Detection of neurotoxicity induced by prospective new therapies represents a major challenge due to the morphological and physiological complexity of the central nervous system (CNS). Characterised by uncontrolled electrical activity in the brain, seizure liability remains a significant cause of attrition in drug [...]
Innovative Models for In Vitro Detection of Seizure ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer [...]
Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting Dr Michael Morton, Director and Co-Founder will be speaking at the 10th Nanion User Meeting on Thursday 17th of October, "Two Years of Experience and Learning with Patchliner". The User Meeting is being held from Wednesday 17th to Thursday 18th [...]
ApconiX Conduct Pilot Study with Axion Biosystems We were thrilled to welcome Jayne Ingram from Axion Biosystems into the ApconiX laboratory to conduct a pilot study using their Maestro Pro microelectrode array (MEA) system and Ncardia iPSC-derived neuronal cells. The cells were cultured for three weeks before Jayne arrived [...]
ApconiX Opens a New Office in Sweden ApconiX is excited to announce the opening of our new office in Sweden. The subsidiary ApconiX AB will be located at AstraZeneca’s BioVentureHub in Gothenburg. ApconiX was formed by Dr Richard Knight, Dr Michael Morton and Professor Ruth Roberts in 2015 and [...]
Dr Michael Morton will be speaking at EUROTOX this September in Belgium. On Tuesday September 4th at 16:30 in Hall 100 Mike will address ‘Cardiac safety: current state of the art’ chaired by Dr Mark Holbrook of VAST Pharma solutions and Ester Lovsin-Barle from Lonza. Mike will present ‘Ion channel profiling of stem cell-derived cardiomyocytes: [...]
George joins ApconiX as a placement student for the month of August. George graduated from the University of Newcastle last year after studying Biology. He decided to take a year out before beginning a master’s degree in stem cell technology and regenerative medicine at the University of Nottingham in September. George was keen to gain [...]
Abstract K+/Cl- cotransporter 2 (KCC2) is selectively expressed in the adult nervous system and allows neurons to maintain low intracellular Cl- levels. Thus, KCC2 activity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated by type A γ-aminobutyric acid (GABAA) receptors, which are Cl--permeable, ligand-gated ion channels. Consistent with this, deficits in the activity of [...]
Read more here: RA Cardarelli, K Jones, LI Pisella, HJ Wobst, LJ McWilliams, PM Sharpe, MP Burnham, DJ Baker, I Chudotvorova, J Guyot, L Silayeva, DH Morrow, N Dekker, S Zicha, PA Davies, J Holenz, ME Duggan, J Dunlop, RJ Mather, Q Wang, I Medina, NJ Brandon, TZ Deeb and SJ Moss. The small molecule CLP257 [...]
As we get ready for a busy and exciting 2017, it’s a good time to reflect on ApconiX’s first full year in business and share some notable highlights. In 2016 we were joined by several additional preclinical experts including Dr Guy Healing, Dr Damian Deavall, Dr Jane Barber, Dr Mike O’Donovan and Dr Peter Ballard [...]
