Avatar

About Kim Rockley

Kim Rockley, PhD. Kim holds a PhD in Pharmacy from Durham University where she studied anthracycline-induced cardiotoxicity and its mitigation by in vitro. Before this, Kim gained with a BSc in Biomedical Science and a Master’s degree in Cancer Pharmacology from the University of Bradford, graduating with distinction. She also has experience as a Clinical Trial Coordinator at the Haematology and Oncology Centre, University Hospitals Bristol NHS foundation Trust. Kim is a creative research scientist who enjoys the busy and dynamic environment of ApconiX.

Seizure Toxicology Research Paper Published

Introduction: Detection of neurotoxicity induced by prospective new therapies represents a major challenge due to the morphological and physiological complexity of the central nervous system (CNS). Characterised by uncontrolled electrical activity in the brain, seizure liability remains a significant cause of attrition in drug discovery and development. An industry survey published in 2016 reported that [...]

By |2020-01-30T14:18:00+00:00January 22nd, 2020|Publications|Comments Off on Seizure Toxicology Research Paper Published

Alleviating the Long-term Cardiotoxicity of Cancer Therapies

Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Her research utilised in vitro cardiomyocyte models to investigate the link between angiotensin signalling and anthracycline-induced cardiotoxicity. Here she describes the problem of cancer therapy induced cardiotoxicity and the potential impact of her [...]

By |2020-03-11T16:19:56+00:00January 16th, 2020|Toxicology|Comments Off on Alleviating the Long-term Cardiotoxicity of Cancer Therapies

Innovative Models for In Vitro Detection of Seizure

ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer the opportunity to screen for seizure liability in vitro, avoiding costly failures in preclinical [...]

By |2019-11-20T15:45:04+00:00November 20th, 2019|Ion Channels, Publications|Comments Off on Innovative Models for In Vitro Detection of Seizure

ApconiX Conduct Pilot Study with Axion Biosystems

We were thrilled to welcome Jayne Ingram from Axion Biosystems into the ApconiX laboratory to conduct a pilot study using their Maestro Pro multielectrode array (MEA) system and Ncardia iPSC-derived neuronal cells.  The cells were cultured for three weeks before Jayne arrived to allow the formation of neuronal networks, which would allow us to assess [...]

By |2019-10-10T10:10:14+01:00October 10th, 2019|Ion Channels, Toxicology|Comments Off on ApconiX Conduct Pilot Study with Axion Biosystems