The Evolving Role of Ion Channels in Shaping Successful Drug Discovery – Live Webinar

For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery. Join Dr Michael Morton, Director and Co-founder of ApconiX in a live webinar on Thursday, November 19th 2020 at 11am EST (4pm GMT). In this free webinar, hosted by Xtalks, attendees will learn [...]

By |2021-04-12T13:22:01+01:00November 4th, 2020|Events|Comments Off on The Evolving Role of Ion Channels in Shaping Successful Drug Discovery – Live Webinar

ApconiX Welcomes Dr Laurence Bishop

ApconiX is delighted to welcome Dr Laurence Bishop to the team as our Head of Business Development.  Laurence is an experienced DMPK and toxicological scientist with 20 years’ experience of nonclinical drug development.  Specialising in business development for the past 13 years, we are looking forward to Laurence playing a key role in our growth [...]

By |2020-11-23T15:09:44+00:00May 28th, 2020|Careers|Comments Off on ApconiX Welcomes Dr Laurence Bishop

Dr Guy Healing Appointed Honorary Professor

ApconiX is pleased to announce that Dr Guy Healing has been appointed to an Honorary Professorship in the School of Pharmacy at the University of East Anglia (UEA), Norwich, UK. Guy first became involved with the UEA when he worked for AstraZeneca.  One of the University’s PhD projects was co-sponsored by AstraZeneca and Guy was [...]

By |2021-04-01T07:45:35+01:00May 20th, 2020|Press|Comments Off on Dr Guy Healing Appointed Honorary Professor

ApconiX Welcomes Charlotte North

ApconiX welcomes Charlotte North to the team.  Charlotte graduated from Sheffield University in July with a degree in Biomedical Sciences and is working in the ApconiX Ion Channel Laboratory as an industry placement student this month. Charlotte has been spending her time, since graduating, exploring the many opportunities the pharmaceutical industry can offer.  She is [...]

By |2020-02-13T16:12:43+00:00February 13th, 2020|Careers|Comments Off on ApconiX Welcomes Charlotte North

An Ascorbate-Induced Increase in Sodium Current

The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles.  Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, ascorbic acid. The Science Firstly, it was important to examine any potential [...]

By |2020-01-30T14:52:24+00:00January 16th, 2020|Ion Channels|Comments Off on An Ascorbate-Induced Increase in Sodium Current

Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, chemistry and patient.  For example, T: what are the safety implications of modulating the target?  C: What are the likely [...]

By |2019-08-07T15:17:44+01:00August 7th, 2019|Toxicology|Comments Off on Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

Sophion’s Ion Channel Modulation Symposium

Dr Michael Morton will be attending Sophion’s Ion Channel Modulation Symposium, on the 19th to 20th of June 2019, at Clare College in Cambridge, UK. Sophion was founded almost twenty years ago by a group of passionate electrophysiologists and offers the some of the most flexible automated patch clamp systems on the market today. The [...]

By |2019-06-07T10:18:56+01:00June 12th, 2019|Events, Ion Channels|Comments Off on Sophion’s Ion Channel Modulation Symposium

ApconiX Joins the MDC’s Virtual R&D platform

ApconiX has joined the Medicines Discovery Catapult’s Virtual R&D platform.  This is a unique national network of consultants, private sector CROs, expert labs and public sector centres of excellence, providing medicines discovery expertise, services and virtual programme management. ApconiX specialises in ion channel biology, target safety assessments and in all aspects of nonclinical programme design [...]

By |2019-06-07T10:20:14+01:00June 6th, 2019|Ion Channels|Comments Off on ApconiX Joins the MDC’s Virtual R&D platform

Professor Ruth Roberts Joins Bio Integrates Panel

Professor Ruth Roberts, Co-founder and Director of ApconiX will join Professor Paul Stott, Chief Executive Officer of Seda Pharmaceutical Development Services, Dr Steve McConchie, Chief Executive Officer of Aptus Clinical and Dr Matt Cooper, Business Development & Marketing Director of National Institute for Health Research to discuss “Collaborating Across the Value Chain to Translate Great [...]

By |2019-05-08T10:04:15+01:00May 8th, 2019|Toxicology, Events|Comments Off on Professor Ruth Roberts Joins Bio Integrates Panel

30th Symposium on Medicinal Chemistry in Eastern England

Dr Michael Morton will be attending the 30th Symposium on Medicinal Chemistry in Eastern England at Hatfield, United Kingdom on 2nd May 2019. This is a highly successful, long-standing, one-day annual meeting. To commemorate 30 years, the programme will focus on ‘Celebrating UK Drug Discovery’, highlighting success stories from large pharma, biotech and academia; and [...]

By |2019-04-24T14:56:18+01:00April 25th, 2019|Events, Ion Channels|Comments Off on 30th Symposium on Medicinal Chemistry in Eastern England