ApconiX Toxicology Archives
Dr Michael Morton, Professor Ruth Roberts, Dr Richard Knight and Dr Paul Duffy will be attending EUROTOX this September in Brussels. The theme for 2018 is “Toxicology Out of the Box” and reflects the federation’s willingness and enthusiasm to offer an innovative, forward-looking and imaginative scientific programme. ‘"The theme for EUROTOX aligns perfectly with our [...]
Ruth Roberts and Emma Walker were featured on the front cover of Toxicology Research this month. The mother and daughter’s review article, Collaboration and competition: ethics in toxicology hit the headlines in Volume 7. The front cover was painted by Emma, an accomplished artist as well as scientist. Emma is currently studying for her Master’s [...]
Many companies involved in cancer drug research and development need to re-think their use of safety data in helping to bring new drugs to cancer patients. Dr Richard Knight of Alderley Park-based ApconiX told last month’s conference, Accelerating Cancer Drug Development – from target to patients, that greater focus on pre-clinical safety should be fundamental to [...]
Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study. Abstract: Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as [...]
Redx Pharma has commenced a Phase I study for a novel cancer treatment at The Christie in Manchester. The compound, RXC004, is a novel, oral, potent small molecule Porcupine inhibitor, and targets the Wnt pathway that is implicated in the maintenance of cancer stem cells. ApconiX were proud to work with our Redx colleagues in [...]
This recent article in the Sunday Times discusses how an extract of magic mushrooms may be able to make significant improvements in the treatment of severe depression. We were delighted to bring ApconiX's drug project toxicologist expertise to the team of experts working with COMPASS Pathways to find a safe, efficient and effective route into [...]
Two of the biggest ethical challenges in pharmaceutical toxicology are the use of animals in testing and the high safety-related attrition rates in new drug development. Yet very little is invested in these two fields compared with investment in new efficacy models, new disease targets and new technologies. How can this be addressed? In this [...]
Guy Healing was recently selected from many applicants to join the panel of the UK register of toxicologists. The UKRT was created in 1993 in response to the need for international harmonization and mutual recognition of toxicologists and is sponsored by The Royal Society of Biology and the British Toxicology Society. By identifying professional toxicologists [...]
Abstract Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic/prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover [...]
Ruth Roberts is first author on one of Toxicological Sciences’ top 10% downloaded articles during the last 2 years. The paper, ‘Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward’ describes the challenges and opportunities in the development of biomarkers of neurotoxicity, a goal shared by scientists across academia, [...]
