ApconiX Ion Channels archive
ApconiX Is Recruiting an Expert Electrophysiologist ApconiX is a team of world-renowned nonclinical safety experts with over 400 years of drug discovery and development expertise. We were formed in 2015 by three scientists with the drive and ambition to create a world-renowned company. We are now looking to grow our [...]
Cardiac Safety in Drug Development: CiPA In the second of a three-part series looking at cardiac safety testing in early drug discovery, Dr Michael Morton of ApconiX considers the CiPA initiative and how its integrated approach sits alongside existing strategies. What is the CiPA initiative and what does it [...]
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
Innovative Models for In Vitro Detection of Seizure ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer [...]
Read the poster Dr Kim Rockley and Dr Michael Morton presented at ELRIG 2019 in Liverpool.
Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting Dr Michael Morton, Director and Co-Founder will be speaking at the 10th Nanion User Meeting on Thursday 17th of October, "Two Years of Experience and Learning with Patchliner". The User Meeting is being held from Wednesday 17th to Thursday 18th [...]
ApconiX Conduct Pilot Study with Axion Biosystems We were thrilled to welcome Jayne Ingram from Axion Biosystems into the ApconiX laboratory to conduct a pilot study using their Maestro Pro microelectrode array (MEA) system and Ncardia iPSC-derived neuronal cells. The cells were cultured for three weeks before Jayne arrived [...]
ApconiX Are in Boston, USA at the End of August Dr Richard Knight and Professor Ruth Roberts are travelling to Boston at the end of August to meet with old colleagues and new contacts, promoting the company’s services in Project Toxicology, Ion Channel Screening and Assay Development, Target Safety [...]
ApconiX Welcomes Priscilla Dumenu ApconiX is delighted to welcome Priscilla Dumenu for a 2-week placement. Priscilla will be working alongside Dr Michael Morton and Dr Karen Jones in the Ion Channel laboratory. Priscilla has just finished her second year studying Pharmacy at the University of Manchester. The 5-year integrated master’s degree [...]
![Cardiac Safety In Drug Development [Cipa] | Apconix](https://www.apconix.com/wp-content/uploads/2019/11/CIPA-Image-320x202.jpg "Cardiac Safety In Drug Development: Cipa 2")
