K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Dr Michael Morton co-authored a paper recently published in the Journal of Cardiovascular Electrophysiology. The paper should serve as a reminder that ion channels which may not be the focus of regulatory guidance or the latest CiPA initiative, still play a critical role in cardiac function, and shouldn’t be forgotten. TASK‐1 (K2P3.1) is a member [...]

By |2019-04-18T10:09:25+01:00April 18th, 2019|Ion Channels, Publications|Comments Off on K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

ApconiX is supporting PhysioStim at SPS

ApconiX and PhysioStim will be celebrating their first year of The European Centre of Excellence for preclinical cardiovascular electrophysiology at the Safety Pharmacology Society Annual Meeting in Washington this September.  ApconiX will be supporting PhysioStim as they exhibit at the Marriott Wardman Park Hotel on Stand 412 from the 30th of September to the 3rd [...]

By |2018-09-25T18:23:43+01:00September 26th, 2018|Ion Channels, Events|Comments Off on ApconiX is supporting PhysioStim at SPS

Xenogesis & Sygnature Hosted Meeting

ApconiX enjoyed a double-billing at the recent ‘Predictive Toxicology in Discovery DMPK’ meeting hosted by Sygnature Discovery and Xenogesis in Nottingham.  Ruth Roberts kicked off the event with the keynote address entitled ‘Roberts Derisking early drug projects Shortened Version March 2018’ (click the title for pdf).  Mike Morton addressed the conference later on in the [...]

By |2018-06-06T15:26:57+01:00March 23rd, 2018|Events|Comments Off on Xenogesis & Sygnature Hosted Meeting

New Drug Discovery Alliance to Tackle High Rate of Failure

Two prominent preclinical safety companies have launched a unique European alliance to address the high safety-related failure rate in drug development. This alliance will provide both high-throughput ion channel screening, advanced cardiovascular safety testing models and experienced project scientists in one collaborative team. This enables both large and small pharmaceutical companies to make the right [...]

By |2018-06-27T16:34:31+01:00September 20th, 2017|Press|Comments Off on New Drug Discovery Alliance to Tackle High Rate of Failure