Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help. We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, [...]
Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia Abstract: Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good [...]
How Alderley Park Grew into an Innovation Hub A great piece in the Financial Times this week “How Alderley Park Grew into an Innovation Hub” which highlights the success of Alderley Park following AstraZeneca’s announced departure 5 years ago. Ned Wakeman talks about his team’s continued support of the start-up companies [...]
The Reductionist Approach The hERG assay has been a mainstay of safety screening in drug discovery for the last 2 decades. Aided by the development of high throughput automated technology, this important assay has brought unparalleled progress in our ability to design safer drugs without those properties that may lead to [...]
Dr Kimberly Rockley Wins EUROTOX Fellowship Grant ApconiX was delighted to hear that Dr Kimberly Rockley had received a EUROTOX Fellowship Grant to attend the Gordon Research Seminar and Conference in the USA this August. The Cellular and Molecular Mechanisms of Toxicity Conference “Integration of Emerging Technologies in Mechanistic and Translational [...]
ApconiX Welcomes Priscilla Dumenu ApconiX is delighted to welcome Priscilla Dumenu for a 2-week placement. Priscilla will be working alongside Dr Michael Morton and Dr Karen Jones in the Ion Channel laboratory. Priscilla has just finished her second year studying Pharmacy at the University of Manchester. The 5-year integrated master’s degree [...]
ApconiX Welcomes William O'Brien ApconiX is delighted to welcome William O'Brien as their new Finance Director. William has a strong background in high-tech development management and corporate finance. William is the founder of WOCO, a specialist R&D tax and financial advisory business based at Alderley Park, Cheshire. A seasoned leader, he [...]
ApconiX Welcomes Rosie Tennant ApconiX is delighted to welcome Rosie Tennant, who joins us for work experience this week. Rosie will be working with Dr Michael Morton and Dr Karen Jones in the ion channel laboratory. Rosie is in Year 12 at The Fallibroome Academy, a secondary and sixth form college [...]
ApconiX Chooses Macmillan Cancer Support as Their Charity of the Year. There are few of us who have not been touched by cancer in one way or another and many of us know family and friends that have been helped or are being supported by Macmillan Cancer Support. Macmillan [...]
Sophion’s Ion Channel Modulation Symposium Dr Michael Morton will be attending Sophion’s Ion Channel Modulation Symposium, on the 19th to 20th of June 2019, at Clare College in Cambridge, UK. Sophion was founded almost twenty years ago by a group of passionate electrophysiologists and offers the some of the [...]
