Inhibition of neuronal ion channels can adversely affect the balance of excitation and inhibition in the brain and negatively impact a drug’s probability of success, value and competitiveness. By working with ApconiX you will benefit from our combined expertise in ion channel electrophysiology, hiPSC-neuronal cell models and project toxicology to identify risks, gain mechanistic insight and prioritise the right candidates moving forward.
Our electrophysiology experts will rapidly generate high-quality seizure panel screening data for your drug discovery programme and aim to return this data in two weeks.
Our hiPSC-neuronal cell model experts can assess compound effects on electrical signalling. This can reveal perturbations to ion channel activity and other important regulators of neuronal function.