Practical Application of Toxicology in Drug Development

Professor Ruth Roberts, Co-founder and Director of ApconiX will be joining Rob Wallis and other eminent scientists in delivering training at the highly acclaimed course Practical Application of Toxicology in Drug Development.  The course, co-organised by the British Toxicology Society and the American College of Toxicology will be held at The Møller Centre, Churchill College, [...]

By |2019-05-08T10:47:02+01:00May 9th, 2019|Toxicology, Events|Comments Off on Practical Application of Toxicology in Drug Development

Professor Ruth Roberts Joins Bio Integrates Panel

Professor Ruth Roberts, Co-founder and Director of ApconiX will join Professor Paul Stott, Chief Executive Officer of Seda Pharmaceutical Development Services, Dr Steve McConchie, Chief Executive Officer of Aptus Clinical and Dr Matt Cooper, Business Development & Marketing Director of National Institute for Health Research to discuss “Collaborating Across the Value Chain to Translate Great [...]

By |2019-05-08T10:04:15+01:00May 8th, 2019|Toxicology, Events|Comments Off on Professor Ruth Roberts Joins Bio Integrates Panel

Identification of Selective Inhibitors of The Epithelial Sodium Channel 𝛿.

Victoria Miller, a PhD student from the Drug Discovery Centre at the University of Sussex recently spent a few months working in the ApconiX ion channel laboratory as a part of her research. Her PhD project titled “Identification of Potent and Selective Inhibitors of the Epithelial Sodium Channel 𝛿”, was supervised by Professors Martin Gosling [...]

By |2019-04-24T15:32:21+01:00May 1st, 2019|Ion Channels, Events|Comments Off on Identification of Selective Inhibitors of The Epithelial Sodium Channel 𝛿.

ApconiX Welcomes Ian Slater to the Team

ApconiX is delighted to welcome Ian Slater to the team.  Ian has spent many years in the pharmaceutical industry as a toxicology Study Director and Study Monitor and he joins our nonclinical study monitoring team.  Ian was previously an Associate Principal Toxicologist in the Regulatory Safety group at AstraZeneca and has a wealth of experience [...]

By |2019-04-25T14:22:47+01:00April 30th, 2019|Uncategorised|Comments Off on ApconiX Welcomes Ian Slater to the Team

30th Symposium on Medicinal Chemistry in Eastern England

Dr Michael Morton will be attending the 30th Symposium on Medicinal Chemistry in Eastern England at Hatfield, United Kingdom on 2nd May 2019. This is a highly successful, long-standing, one-day annual meeting. To commemorate 30 years, the programme will focus on ‘Celebrating UK Drug Discovery’, highlighting success stories from large pharma, biotech and academia; and [...]

By |2019-04-24T14:56:18+01:00April 25th, 2019|Ion Channels, Events|Comments Off on 30th Symposium on Medicinal Chemistry in Eastern England

Toxicological Sciences: From the Editor’s Desk, Editor’s Highlights

One of the recent Editor's Highlights in Toxicological Sciences was a paper by Peters et al., on GI Barrier and Drug-induced Diarrhea, reviewed by  Professor Ruth Roberts, an Associate Editor of Toxicological Sciences. As Ruth highlighted, attrition in drug discovery and development due to toxicity remains a major challenge. A plethora of preclinical in vitro models [...]

By |2019-04-24T14:58:09+01:00April 24th, 2019|Toxicology, Publications|Comments Off on Toxicological Sciences: From the Editor’s Desk, Editor’s Highlights

K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

Dr Michael Morton co-authored a paper recently published in the Journal of Cardiovascular Electrophysiology. The paper should serve as a reminder that ion channels which may not be the focus of regulatory guidance or the latest CiPA initiative, still play a critical role in cardiac function, and shouldn’t be forgotten. TASK‐1 (K2P3.1) is a member [...]

By |2019-04-18T10:09:25+01:00April 18th, 2019|Ion Channels, Publications|Comments Off on K2p3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall

British Toxicology Society Congress a Great Success

Dr Richard Knight, Dr Guy Healing, Professor Ruth Roberts, Phumzile Sikakana and Dr Karin Burnett thoroughly enjoyed the British Society of Toxicology Congress this week at Robinson College, University of Cambridge. Highlights of the meeting included a great opening keynote from Dr Stefan Platz (AstraZeneca) who shared his vision for the use of AI in [...]

By |2019-04-18T10:14:42+01:00April 18th, 2019|Toxicology, Events|Comments Off on British Toxicology Society Congress a Great Success

Toxicogenomics: A 2020 Vision

Together with the promotion of non-animal testing, in vitro toxicogenomics (TGx) may play a vital role in the next generation risk assessment paradigm. A strategic shift in risk assessment provides an unprecedented opportunity for repositioning TGx in the regulatory setting. As the emerging technique continues to impact the TGx field, novel genomic features such as [...]

By |2019-04-17T15:54:02+01:00April 17th, 2019|Toxicology, Publications|Comments Off on Toxicogenomics: A 2020 Vision

ApconiX Attends British Toxicology Society Congress – “Celebrating 40 years of the BTS”.

British Toxicology Society (BTS) and the UK Environmental Mutagen Society Annual Congress “Celebrating 40 years of the BTS" will be held at Robinson College, University of Cambridge between 15th -17th of April. Professor Ruth Roberts, Dr Richard Knight, Dr Guy Healing and Phumzile Sikakana will all be attending.  Ruth will be presented with an Honorary Fellowship [...]

By |2019-04-14T16:01:01+01:00April 14th, 2019|Toxicology, Events|Comments Off on ApconiX Attends British Toxicology Society Congress – “Celebrating 40 years of the BTS”.