Acuity Target Safety Assessments: Knowledge is Power

A thorough understanding of potential target-related effects is crucial to making the right choices in drug discovery.  Experienced project toxicologists extract and interpret data from mouse knockouts, human gene mutations and known effects of modulators to determine the potential consequences of target inhibition or activation in each organ system. Target Safety Assessments are pivotal in [...]

By |2019-10-01T14:04:36+01:00October 1st, 2019|Target Safety Assessments|Comments Off on Acuity Target Safety Assessments: Knowledge is Power

“The World’s Biggest Coffee Morning” at Alderley Park

On the 26th of September we hosted a Macmillan coffee at Alderley Park.  It was a lovely morning where we all came together for a cuppa, some delicious home baking and a chat, all in aid of Macmillan Cancer Support.  We had Pimm’s cupcakes, vegan carrot cake, lemon drizzle cake, banana loaf, individual Victoria sponges [...]

By |2019-09-27T15:30:43+01:00September 27th, 2019|Events|Comments Off on “The World’s Biggest Coffee Morning” at Alderley Park

Another Half Marathon Completed in Aid of Macmillan Cancer Support!

Phumzile Sikakana talks about part two of her Triple Half Marathon Challenge. “Last Sunday 22nd of September I ran the Macc-Fest Half Marathon in Macclesfield marking two-thirds of the way through my triple half marathon journey, and it was a hilly one!  Although I didn’t manage to get a personal best, I was the 33rd [...]

By |2019-09-25T14:36:24+01:00September 25th, 2019|Events|Comments Off on Another Half Marathon Completed in Aid of Macmillan Cancer Support!

Is Expert Interpretation as Good as Complex Computational Modelling?

Come and complete the questionnaire Dr Hitesh Mistry has developed to investigate whether expert interpretation of data is as good as complex computational modelling at the Safety Pharmacology Society Annual Meeting at Barcelona this week.  ApconiX will have copies of the questionnaire on their stand number 307. Dr Hitesh Mistry is a computational modelling expert [...]

By |2019-09-23T19:32:19+01:00September 23rd, 2019|Events|Comments Off on Is Expert Interpretation as Good as Complex Computational Modelling?

Dr Kimberly Rockley Presents at the 2019 Gordon Research Conference

Dr Kimberly Rockley and Professor Ruth Roberts had a fabulous time at the Gordon Research Seminar (GRS) and Conference (GRC) earlier this month.  GRCs provide an international forum for the presentation and discussion of cutting-edge research in science; GRSs are organised by and for young investigators and take place alongside the GRC. L to [...]

By |2019-09-04T14:03:05+01:00September 5th, 2019|Events|Comments Off on Dr Kimberly Rockley Presents at the 2019 Gordon Research Conference

Half Marathon Triple Challenge in Aid of Macmillan Cancer Support

Phumzile Sikakana talks about the first part of her Triple Half Marathon Challenge. “On Sunday the 1st of September 2019 I completed my first ever half marathon. I ran the Cheshire Half at Capesthorne Hall as part of my Half Marathon Triple Challenge. I was the 37th woman to cross the finish line in a [...]

By |2019-09-04T12:47:24+01:00September 4th, 2019|Events|Comments Off on Half Marathon Triple Challenge in Aid of Macmillan Cancer Support

ApconiX Are in Boston, USA at the End of August

Dr Richard Knight and Professor Ruth Roberts are travelling to Boston at the end of August to meet with old colleagues and new contacts, promoting the company’s services in Project Toxicology, Ion Channel Screening and Assay Development, Target Safety Assessments and all aspects of Nonclinical Programme Design. They will be joined by Dr Andrew Winkley. [...]

By |2019-08-20T17:40:25+01:00August 20th, 2019|Ion Channels, Target Safety Assessments, Toxicology, Events|Comments Off on ApconiX Are in Boston, USA at the End of August

Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, chemistry and patient.  For example, T: what are the safety implications of modulating the target?  C: What are the likely [...]

By |2019-08-07T15:17:44+01:00August 7th, 2019|Toxicology|Comments Off on Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia

Abstract: Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in [...]

By |2019-08-07T10:14:32+01:00August 6th, 2019|Publications|Comments Off on Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia

How Alderley Park Grew into an Innovation Hub

A great piece in the Financial Times this week “How Alderley Park Grew into an Innovation Hub” which highlights the success of Alderley Park following AstraZeneca’s announced departure 5 years ago.  Ned Wakeman talks about his team’s continued support of the start-up companies and Dr Chris Doherty explains the vision of the site that will [...]

By |2019-08-01T09:03:51+01:00July 31st, 2019|Press|Comments Off on How Alderley Park Grew into an Innovation Hub