My Brush with Greatness

It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this time, Neher and Sakmann had recruited a Post Doc called [...]

By |2020-01-30T14:21:05+00:00January 16th, 2020|Ion Channels|Comments Off on My Brush with Greatness

An Ascorbate-Induced Increase in Sodium Current

The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles.  Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, ascorbic acid. The Science Firstly, it was important to examine any potential [...]

By |2020-01-30T14:52:24+00:00January 16th, 2020|Ion Channels|Comments Off on An Ascorbate-Induced Increase in Sodium Current

Alleviating the Long-term Cardiotoxicity of Cancer Therapies

Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Her research utilised in vitro cardiomyocyte models to investigate the link between angiotensin signalling and anthracycline-induced cardiotoxicity. Here she describes the problem of cancer therapy induced cardiotoxicity and the potential impact of her [...]

By |2020-03-11T16:19:56+00:00January 16th, 2020|Toxicology|Comments Off on Alleviating the Long-term Cardiotoxicity of Cancer Therapies

Dr Kimberly Rockley’s First Six Months at ApconiX

Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Here she reflects on her first 6 months with the company. “Having gained a background in cancer biology, toxicology and in vitro research techniques from my Master’s degree and PhD research I was [...]

By |2020-01-22T13:34:12+00:00January 16th, 2020|Careers|Comments Off on Dr Kimberly Rockley’s First Six Months at ApconiX

Merry Christmas and a Happy New Year

Team ApconiX had a fabulous time at their Christmas party - secret Santa brought tears of laughter and sorrow and the odd gasp!  A few team members went incognito. Wishing everyone a lovely holiday and the very best for the coming year.  Looking forward to a new decade and new challenges.  See you in 2020!

By |2019-12-19T18:42:35+00:00December 19th, 2019|Events|Comments Off on Merry Christmas and a Happy New Year

Dr Michael Morton Attends Genedata Biopharma Open Forum

Dr Michael Morton is attending “Accelerating Biopharma R&D with Innovative Biopharma Data Management and Analysis” at the Swiss Embassy in London today.  The event was organised by Genedata. Speakers include Dr Peter Whitfield, Senior Scientific Data Analyst at GSK, Chris Wilson, Senior Scientist at Crescendo Biologics Limited, Alex Stowell, Lead Biologist at CRUK Manchester Institute [...]

By |2019-12-04T14:11:05+00:00December 4th, 2019|Events|Comments Off on Dr Michael Morton Attends Genedata Biopharma Open Forum

Festive Charity Fundraisers

ApconiX would like to congratulate Andrew Walker from BioScript for correctly guessing the number of sweets in the jar. There were 199 in total, lucky Andy gets to walk away with all that delicious Lindt chocolate! We have now raised  over a £1000 since the summer for our charity of the year, Macmillan Cancer Support. [...]

By |2019-11-28T15:23:50+00:00November 28th, 2019|Events|Comments Off on Festive Charity Fundraisers

Innovative Models for In Vitro Detection of Seizure

ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer the opportunity to screen for seizure liability in vitro, avoiding costly failures in preclinical [...]

By |2019-11-20T15:45:04+00:00November 20th, 2019|Ion Channels, Publications|Comments Off on Innovative Models for In Vitro Detection of Seizure

ApconiX Is Presenting a Poster at ELRIG 2019

ApconiX is delighted to be presenting a poster at ELRIG 2019 titled “Sodium channel selectivity of two anti-epileptic drugs.”  The poster includes research started by our placement student Priscilla Dumenu. Dr Michael Morton, Dr Richard Knight, Dr Kimberly Rockley, Phumzile Sikakana and Olivia Turner are all attending the conference. “I am really looking forward to [...]

By |2019-10-30T15:08:26+00:00October 30th, 2019|Events|Comments Off on ApconiX Is Presenting a Poster at ELRIG 2019