The Evolving Role of Ion Channels in Shaping Successful Drug Discovery - Live Webinar For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery. Join Dr Michael Morton, Director and Co-founder of ApconiX in a live webinar on [...]
Science-Driven Design of the Preclinical Strategy: Case by Case Join Professor Ruth Roberts for the next science webinar in the Alderley Park Science Seminar Series: Science-Driven Design of the Preclinical Strategy: Case by Case Tuesday, 11 August 2020 12:00 pm to 1:00 pm Ruth will present lessons learned from >20 years’ [...]
Discover the Power of Target Safety Assessments in a SOT EHS Webinar Professor Ruth Roberts, Dr Claire Sadler and Dr Leigh Ann Burns Nass present Target Safety Assessments: Knowledge is Power webinar in a SOT 2020 Exhibitor Hosted Session. Membership of SOT is not required. Registration for the webinar [...]
ApconiX Welcomes Dr Laurence Bishop ApconiX is delighted to welcome Dr Laurence Bishop to the team as our Head of Business Development. Laurence is an experienced DMPK and toxicological scientist with 20 years’ experience of nonclinical drug development. Specialising in business development for the past 13 years, we are [...]
ApconiX Co-organises British Toxicology Society Meeting The meeting that ApconiX is co-organising the British Toxicology Society “Science-led Strategies for Success in Discovery and Development Toxicology” is being rearranged for a date later in 2020 - watch this space for updates! Sponsored by Lonza and AstraZeneca and co-organised by ApconiX, [...]
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
Acuity Target Safety Assessments: Knowledge is Power A thorough understanding of potential target-related effects is crucial to making the right choices in drug discovery. Experienced project toxicologists extract and interpret data from mouse knockouts, human gene mutations and known effects of modulators to determine the potential consequences of target inhibition or [...]
Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help. We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, [...]
Dr Kimberly Rockley Wins EUROTOX Fellowship Grant ApconiX was delighted to hear that Dr Kimberly Rockley had received a EUROTOX Fellowship Grant to attend the Gordon Research Seminar and Conference in the USA this August. The Cellular and Molecular Mechanisms of Toxicity Conference “Integration of Emerging Technologies in Mechanistic and Translational [...]
