Science-Driven Design of the Preclinical Strategy: Case by Case

Join Professor Ruth Roberts for the next science webinar in the Alderley Park Science Seminar Series: Science-Driven Design of the Preclinical Strategy: Case by Case Tuesday, 11 August 2020 12:00 pm to 1:00 pm Ruth will present lessons learned from >20 years’ experience in the pharmaceutical industry focusing on attrition, prediction and the challenges posed by nonclinical [...]

By |2020-08-05T14:01:54+01:00August 5th, 2020|Events|Comments Off on Science-Driven Design of the Preclinical Strategy: Case by Case

Discover the Power of Target Safety Assessments in a SOT EHS Webinar

Professor Ruth Roberts, Dr Claire Sadler and Dr Leigh Ann Burns Nass present Target Safety Assessments: Knowledge is Power webinar in a SOT 2020 Exhibitor Hosted Session.  Membership of SOT is not required.  Registration for the webinar is free.  

By |2020-07-02T15:47:19+01:00July 2nd, 2020|Events|Comments Off on Discover the Power of Target Safety Assessments in a SOT EHS Webinar

ApconiX Welcomes Dr Laurence Bishop

ApconiX is delighted to welcome Dr Laurence Bishop to the team as our Head of Business Development.  Laurence is an experienced DMPK and toxicological scientist with 20 years’ experience of nonclinical drug development.  Specialising in business development for the past 13 years, we are looking forward to Laurence playing a key role in our growth [...]

By |2020-05-28T17:27:19+01:00May 28th, 2020|Careers|Comments Off on ApconiX Welcomes Dr Laurence Bishop

ApconiX Co-organises British Toxicology Society Meeting

The meeting that ApconiX is co-organising the British Toxicology Society  “Science-led Strategies for Success in Discovery and Development Toxicology” is being rearranged for a date later in 2020 - watch this space for updates! Sponsored by Lonza and AstraZeneca and co-organised by ApconiX, GlaxoSmithKline, Sygnature Discovery and Alderley Park,  the meeting is focused on safety [...]

By |2020-03-19T10:36:26+00:00March 8th, 2020|Events|Comments Off on ApconiX Co-organises British Toxicology Society Meeting

My Brush with Greatness

It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this time, Neher and Sakmann had recruited a Post Doc called [...]

By |2020-01-30T14:21:05+00:00January 16th, 2020|Ion Channels|Comments Off on My Brush with Greatness

An Ascorbate-Induced Increase in Sodium Current

The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles.  Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, ascorbic acid. The Science Firstly, it was important to examine any potential [...]

By |2020-01-30T14:52:24+00:00January 16th, 2020|Ion Channels|Comments Off on An Ascorbate-Induced Increase in Sodium Current

Acuity Target Safety Assessments: Knowledge is Power

A thorough understanding of potential target-related effects is crucial to making the right choices in drug discovery.  Experienced project toxicologists extract and interpret data from mouse knockouts, human gene mutations and known effects of modulators to determine the potential consequences of target inhibition or activation in each organ system. Target Safety Assessments are pivotal in [...]

By |2019-10-01T14:04:36+01:00October 1st, 2019|Target Safety Assessments|Comments Off on Acuity Target Safety Assessments: Knowledge is Power

Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, chemistry and patient.  For example, T: what are the safety implications of modulating the target?  C: What are the likely [...]

By |2019-08-07T15:17:44+01:00August 7th, 2019|Toxicology|Comments Off on Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help.

Dr Kimberly Rockley Wins EUROTOX Fellowship Grant

ApconiX was delighted to hear that Dr Kimberly Rockley had received a EUROTOX Fellowship Grant to attend the Gordon Research Seminar and Conference in the USA this August. The Cellular and Molecular Mechanisms of Toxicity Conference “Integration of Emerging Technologies in Mechanistic and Translational Toxicology” runs from the 11th to the 16th of August and [...]

By |2019-07-24T14:43:16+01:00July 10th, 2019|Toxicology, Events|Comments Off on Dr Kimberly Rockley Wins EUROTOX Fellowship Grant

Sophion’s Ion Channel Modulation Symposium

Dr Michael Morton will be attending Sophion’s Ion Channel Modulation Symposium, on the 19th to 20th of June 2019, at Clare College in Cambridge, UK. Sophion was founded almost twenty years ago by a group of passionate electrophysiologists and offers the some of the most flexible automated patch clamp systems on the market today. The [...]

By |2019-06-07T10:18:56+01:00June 12th, 2019|Ion Channels, Events|Comments Off on Sophion’s Ion Channel Modulation Symposium