ApconiX Co-organises British Toxicology Society Meeting The meeting that ApconiX is co-organising the British Toxicology Society “Science-led Strategies for Success in Discovery and Development Toxicology” is being rearranged for a date later in 2020 - watch this space for updates! Sponsored by Lonza and AstraZeneca and co-organised by ApconiX, [...]
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity Abstract: Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed [...]
Merry Christmas and a Happy New Year Team ApconiX had a fabulous time at their Christmas party - secret Santa brought tears of laughter and sorrow and the odd gasp! A few team members went incognito. Wishing everyone a lovely holiday and the very best for the coming year. [...]
Professor Ruth Roberts is Speaking at the American Association of Pharmaceutical Scientists Professor Ruth Roberts, Co-Founder and Director of ApconiX will be speaking at the American Association of Pharmaceutical Scientists (AAPS) on Monday 4th November at 9:00am in a session entitled "Next Generation Technologies in Preclinical Development” chaired by Dr Shraddha [...]
Acuity Target Safety Assessments: Knowledge is Power A thorough understanding of potential target-related effects is crucial to making the right choices in drug discovery. Experienced project toxicologists extract and interpret data from mouse knockouts, human gene mutations and known effects of modulators to determine the potential consequences of target inhibition or [...]
Dr Kimberly Rockley Presents at the 2019 Gordon Research Conference Dr Kimberly Rockley and Professor Ruth Roberts had a fabulous time at the Gordon Research Seminar (GRS) and Conference (GRC) earlier this month. GRCs provide an international forum for the presentation and discussion of cutting-edge research in science; GRSs are organised [...]
Derisking projects: how a focus on TCP (Target – Chemistry – Patient) can help. We all know drug projects fail – so how can we improve our probability of success? TCP offers a systematic approach to de-risking projects by asking the right questions at the right time around target, [...]
Derivatisation of Parthenolide to Address Chemoresistant Chronic Lymphocytic Leukaemia Abstract: Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good [...]
How Alderley Park Grew into an Innovation Hub A great piece in the Financial Times this week “How Alderley Park Grew into an Innovation Hub” which highlights the success of Alderley Park following AstraZeneca’s announced departure 5 years ago. Ned Wakeman talks about his team’s continued support of the start-up companies [...]
Dr Kimberly Rockley Wins EUROTOX Fellowship Grant ApconiX was delighted to hear that Dr Kimberly Rockley had received a EUROTOX Fellowship Grant to attend the Gordon Research Seminar and Conference in the USA this August. The Cellular and Molecular Mechanisms of Toxicity Conference “Integration of Emerging Technologies in Mechanistic and Translational [...]
