ApconiX Chooses The Joshua Tree as Their Charity of the Year for 2020 Phumzile Sikakana talks about ApconiX’s fundraising for 2019 and looks forward to 2020. “ApconiX have had an absolutely fantastic 6 months of fundraising for Macmillan Cancer Support. Our grand total is an amazing £2000! I'd personally [...]
Seizure Toxicology Research Paper Published Introduction: Detection of neurotoxicity induced by prospective new therapies represents a major challenge due to the morphological and physiological complexity of the central nervous system (CNS). Characterised by uncontrolled electrical activity in the brain, seizure liability remains a significant cause of attrition in drug [...]
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity Abstract: Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed [...]
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
Alleviating the Long-term Cardiotoxicity of Cancer Therapies Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Her research utilised in vitro cardiomyocyte models to investigate the link between angiotensin signalling and anthracycline-induced cardiotoxicity. Here she describes [...]
Dr Kimberly Rockley's First Six Months at ApconiX Kimberly Rockley completed her PhD in the Division of Pharmacy at Durham University before joining us at ApconiX in June last year. Here she reflects on her first 6 months with the company. “Having gained a background in cancer biology, toxicology [...]
Merry Christmas and a Happy New Year Team ApconiX had a fabulous time at their Christmas party - secret Santa brought tears of laughter and sorrow and the odd gasp! A few team members went incognito. Wishing everyone a lovely holiday and the very best for the coming year. [...]
Dr Michael Morton Attends Genedata Biopharma Open Forum Dr Michael Morton is attending “Accelerating Biopharma R&D with Innovative Biopharma Data Management and Analysis” at the Swiss Embassy in London today. The event was organised by Genedata. Speakers include Dr Peter Whitfield, Senior Scientific Data Analyst at GSK, Chris Wilson, [...]
Festive Charity Fundraisers ApconiX would like to congratulate Andrew Walker from BioScript for correctly guessing the number of sweets in the jar. There were 199 in total, lucky Andy gets to walk away with all that delicious Lindt chocolate! We have now raised over £1000 since the summer for [...]
