ApconiX Welcomes Dr Selvan Bavan ApconiX welcomes Dr Selvan Bavan, who joins us to carry out ion channel research using manual patch-clamp while learning more about using automated patch-clamp by working with Dr Michael Morton and Dr Karen Jones. Selvan commented, “Conventional manual patch-clamp is regarded as a ‘gold [...]
COVID-19 Update As we all continue to live through these very difficult times, our main priority is the safety and wellbeing of our staff, their families and the community. As an essential facility in the development of new medicines, we remain fully operational. We are following government guidelines and [...]
ApconiX Co-organises British Toxicology Society Meeting The meeting that ApconiX is co-organising the British Toxicology Society “Science-led Strategies for Success in Discovery and Development Toxicology” is being rearranged for a date later in 2020 - watch this space for updates! Sponsored by Lonza and AstraZeneca and co-organised by ApconiX, [...]
Cardiac Safety in Drug Development: CiPA In the second of a three-part series looking at cardiac safety testing in early drug discovery, Dr Michael Morton of ApconiX considers the CiPA initiative and how its integrated approach sits alongside existing strategies. What is the CiPA initiative and what does it [...]
ApconiX Welcomes Charlotte North ApconiX welcomes Charlotte North to the team. Charlotte graduated from Sheffield University in July with a degree in Biomedical Sciences and is working in the ApconiX Ion Channel Laboratory as an industry placement student this month. Charlotte has been spending her time, since graduating, exploring [...]
ApconiX Chooses The Joshua Tree as Their Charity of the Year for 2020 Phumzile Sikakana talks about ApconiX’s fundraising for 2019 and looks forward to 2020. “ApconiX have had an absolutely fantastic 6 months of fundraising for Macmillan Cancer Support. Our grand total is an amazing £2000! I'd personally [...]
Seizure Toxicology Research Paper Published Introduction: Detection of neurotoxicity induced by prospective new therapies represents a major challenge due to the morphological and physiological complexity of the central nervous system (CNS). Characterised by uncontrolled electrical activity in the brain, seizure liability remains a significant cause of attrition in drug [...]
Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity Abstract: Drug-induced liver injury (DILI) is of significant concern to drug development and regulatory review because of the limited success with existing preclinical models. For developing alternative methods, a large drug list is needed [...]
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
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