ApconiX Ion Channels archive
My Brush with Greatness It is wonderful to see the original publication of patch-clamp methodology included in Nature’s 10 extraordinary papers (published 22 October 2019). The ground-breaking work of Neher and Sakmann sits alongside the discovery of the structure of DNA, cell reprogramming and birth of nanomaterials. At this [...]
An Ascorbate-Induced Increase in Sodium Current The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles. Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, [...]
Innovative Models for In Vitro Detection of Seizure ApconiX is delighted that Dr Kim Rockley's article ‘ Innovative models for in vitro detection of seizure‘ has now been accepted for publication in Toxicology Research. The article highlights how new technologies such as microelectrode array and ion channel screening offer [...]
Read the poster Dr Kim Rockley and Dr Michael Morton presented at ELRIG 2019 in Liverpool.
Dr Michael Morton Is Presenting at 10th Nanion Annual User Meeting Dr Michael Morton, Director and Co-Founder will be speaking at the 10th Nanion User Meeting on Thursday 17th of October, "Two Years of Experience and Learning with Patchliner". The User Meeting is being held from Wednesday 17th to Thursday 18th [...]
ApconiX Conduct Pilot Study with Axion Biosystems We were thrilled to welcome Jayne Ingram from Axion Biosystems into the ApconiX laboratory to conduct a pilot study using their Maestro Pro microelectrode array (MEA) system and Ncardia iPSC-derived neuronal cells. The cells were cultured for three weeks before Jayne arrived [...]
ApconiX Are in Boston, USA at the End of August Dr Richard Knight and Professor Ruth Roberts are travelling to Boston at the end of August to meet with old colleagues and new contacts, promoting the company’s services in Project Toxicology, Ion Channel Screening and Assay Development, Target Safety [...]
The Reductionist Approach The hERG assay has been a mainstay of safety screening in drug discovery for the last 2 decades. Aided by the development of high throughput automated technology, this important assay has brought unparalleled progress in our ability to design safer drugs without those properties that may lead to [...]
ApconiX Welcomes Priscilla Dumenu ApconiX is delighted to welcome Priscilla Dumenu for a 2-week placement. Priscilla will be working alongside Dr Michael Morton and Dr Karen Jones in the Ion Channel laboratory. Priscilla has just finished her second year studying Pharmacy at the University of Manchester. The 5-year integrated master’s degree [...]
Sophion’s Ion Channel Modulation Symposium Dr Michael Morton will be attending Sophion’s Ion Channel Modulation Symposium, on the 19th to 20th of June 2019, at Clare College in Cambridge, UK. Sophion was founded almost twenty years ago by a group of passionate electrophysiologists and offers the some of the [...]
