ApconiX Upgrade to a QPatch ll 48 Automated Patch Clamp to Meet Demand

ApconiX, the integrated toxicology and ion channel company, has acquired a QPatch ll 48 with temperature control to meet the increasing demand from their clients. As the first CRO to invest in QPatch II in the UK, this instrument allows the ApconiX team to continue to deliver top quality ion channel services for their existing [...]

By |2020-12-16T15:08:46+00:00December 16th, 2020|Ion Channels|Comments Off on ApconiX Upgrade to a QPatch ll 48 Automated Patch Clamp to Meet Demand

Dr Michael Morton is Attending the 31st Symposium on Medicinal Chemistry in Eastern England

Dr Michael Morton is attending the 31st symposium on Medicinal Chemistry in Eastern England on Thursday 26th of November.  ApconiX is also exhibiting at the virtual event. Mike commented, “RSC events are always a great collection of people and presentations. With every event I learn new ways in which ApconiX can help and support its [...]

By |2020-11-23T15:03:39+00:00November 11th, 2020|Events|Comments Off on Dr Michael Morton is Attending the 31st Symposium on Medicinal Chemistry in Eastern England

The Evolving Role of Ion Channels in Shaping Successful Drug Discovery – Live Webinar

For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery. Join Dr Michael Morton, Director and Co-founder of ApconiX in a live webinar on Thursday, November 19th 2020 at 11am EST (4pm GMT). In this free webinar, hosted by Xtalks, attendees will learn [...]

By |2021-04-12T13:22:01+01:00November 4th, 2020|Events|Comments Off on The Evolving Role of Ion Channels in Shaping Successful Drug Discovery – Live Webinar

Dr Laurence Bishop Attends Bio-Europe Digital 2020

Dr Laurence Bishop is attending Bio-Europe Digital 2020 from the 26th to the 29th of October. Dr Michael Morton and Dr Richard Knight joined the UK delegation at The UK Pavilion at BIO-Europe last year.  ApconiX benefited from a Tradeshow Access Programme (TAP) grant offered by the Department of International Trade.   “I have fond [...]

By |2020-11-23T15:05:41+00:00October 21st, 2020|Events|Comments Off on Dr Laurence Bishop Attends Bio-Europe Digital 2020

Dr Michael Morton is Attending Safety Pharmacology Society

Dr Michael Morton will be attending the annual Safety Pharmacology Society Meeting being held virtually this year between 14th and 17th of September. Mike will be presenting Poster 030: Electrophysiological analysis of Seroquel’s activity in sodium ion channels, CiPA ion channels and hiPSC-neuronal cells K L Rockley1; K Jones1; R A Roberts1; M J Morton1 [...]

By |2020-10-12T17:34:16+01:00September 10th, 2020|Events|Comments Off on Dr Michael Morton is Attending Safety Pharmacology Society

ApconiX Welcomes Dr Laurence Bishop

ApconiX is delighted to welcome Dr Laurence Bishop to the team as our Head of Business Development.  Laurence is an experienced DMPK and toxicological scientist with 20 years’ experience of nonclinical drug development.  Specialising in business development for the past 13 years, we are looking forward to Laurence playing a key role in our growth [...]

By |2020-11-23T15:09:44+00:00May 28th, 2020|Careers|Comments Off on ApconiX Welcomes Dr Laurence Bishop

ApconiX Welcomes Dr Selvan Bavan

ApconiX welcomes Dr Selvan Bavan, who joins us to carry out ion channel research using manual patch-clamp while learning more about using automated patch-clamp by working with Dr Michael Morton and Dr Karen Jones. Selvan commented, “Conventional manual patch-clamp is regarded as a ‘gold standard’ technique to record ion channel currents, but this technique has [...]

By |2020-04-22T10:37:18+01:00April 15th, 2020|Careers|Comments Off on ApconiX Welcomes Dr Selvan Bavan

ApconiX Welcomes Charlotte North

ApconiX welcomes Charlotte North to the team.  Charlotte graduated from Sheffield University in July with a degree in Biomedical Sciences and is working in the ApconiX Ion Channel Laboratory as an industry placement student this month. Charlotte has been spending her time, since graduating, exploring the many opportunities the pharmaceutical industry can offer.  She is [...]

By |2020-02-13T16:12:43+00:00February 13th, 2020|Careers|Comments Off on ApconiX Welcomes Charlotte North

An Ascorbate-Induced Increase in Sodium Current

The Challenge It is not uncommon for our clients to synthesise compounds for testing in in vitro assays that are largely insoluble, and sometimes this requires consideration of novel vehicles.  Recently, when provided with a DMSO-insoluble compound, we explored using the aqueous solvent, ascorbic acid. The Science Firstly, it was important to examine any potential [...]

By |2020-01-30T14:52:24+00:00January 16th, 2020|Ion Channels|Comments Off on An Ascorbate-Induced Increase in Sodium Current

The Reductionist Approach

The hERG assay has been a mainstay of safety screening in drug discovery for the last 2 decades. Aided by the development of high throughput automated technology, this important assay has brought unparalleled progress in our ability to design safer drugs without those properties that may lead to life-threatening cardiac arrhythmia. In a series of [...]

By |2019-07-24T14:41:23+01:00July 11th, 2019|Ion Channels|Comments Off on The Reductionist Approach