ApconiX is delighted to welcome Dr Sean Hammond who joins us as a Principal Scientist in Immunotoxicology/Immune-oncology and is the latest addition to our growing target safety assessment team.

Sean recently completed his PhD at the University of Liverpool, following on from his first degree in Pharmacology where he received the year prize. His degree projects were conducted at the Wolfson Centre for Personalised Medicine and were entitled ‘Are pregnant women are at increased risk of adverse drug reactions? and ‘The translocation of GLUT4 transporter in response to insulin using innovative techniques’.

Sean’s PhD project was entitled ‘An in-vitro investigation of the role of T-lymphocytes in tolvaptan-associated liver injury and immune checkpoint blockade related hypersensitivity reactions’. Sean worked in an interdisciplinary team to delineate the chemical and biological mechanisms underlying hypersensitivity reactions seen in the clinic, and formulated the experimental and conceptual means to address novel adverse reactions associated with immune checkpoint inhibitors.

Following on from his PhD, Sean was awarded an honorary lectureship at the University of Liverpool where he maintains academic collaborations and research activity in his field. His recent publications include a primary publication on the effects of immune checkpoint inhibitors on the immunological tolerability of concomitant medications, and a review on in-vitro approaches used to diagnose and predict hypersensitivity reactions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076677/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166637/

Sean commented, “ApconiX is truly a team of world renowned experts united by the common aim of honestly and pragmatically informing decision making within drug toxicology. From day one the team has welcomed me, and my values of integrity and collaboration in science are a great fit here. I look forward to lifelong learning and developing as a scientist, and the growing, collaborative environment of ApconiX is a very exciting place to do this.”

“We are delighted to welcome Sean to our growing team here at ApconiX.  He brings significant expertise in the growing field of immune-oncology and will be a huge asset to our target safety assessment team”, added Professor Ruth Roberts, Co-founder and Director of ApconiX.

During his years at University, Sean has had varied employment ranging from a quality control technician at AstraZeneca, a self-employed DIY and gardener, and an undertaker.  He has been a key sportsman, with previous hobbies including powerlifting and being a team member of Macclesfield RUFC. A classic Jaguar enthusiast, Sean also has an interest in other antiques and collectables and can often be found hunting for dusty oak furniture with his fiancée Stephanie at weekends.