About Richard Knight

Dr Richard Knight PhD, ERT, is a Director and Co-founder of ApconiX, a preclinical toxicology and ion channel company that brings together a team of world-renowned nonclinical safety experts. Richard graduated from the University of Bradford in 1989 with a degree in Biomedical Sciences (Pharmacology) before gaining a PhD at the University of Leeds researching the role of adenosine receptors in renal function and toxicity. His research then included post-doctoral studies at University of California, Los Angeles (UCLA) into the effects of ischaemia/reperfusion injury on cardiac metabolism. Richard joined Zeneca Pharmaceuticals, Safety of Medicines Group in 1996 as a Study Director, and then Project Toxicologist across multiple therapy areas, from early discovery through to market. As Lead Toxicologist for Oncology, Richard was a member of both the Drug Safety and Metabolism, and Oncology Leadership teams with responsibility for safety across the AZ oncology portfolio. In this senior role he provided leadership and mentoring support to other project toxicologists. Richard has worked on many drug platforms over this time including small molecules, biologics, proteins and oligonucleotides and has been involved in bringing over 30 new candidate drugs into clinical trials and 5 to marketing approval.

ApconiX Welcomes Dr Bjorn Dahl

ApconiX is delighted to welcome Dr Björn Dahl to the team, who joins our new Swedish office at AstraZeneca’s BioVentureHub in Gothenburg. Björn is a highly respected and experienced toxicologist, having been the co-chair of the European Federation Pharmaceutical Industry Association (EFPIA) Preclinical Development Expert Working Group and served as the EFPIA topic lead in [...]

By |2019-05-08T12:20:38+01:00February 6th, 2019|Toxicology, Careers|Comments Off on ApconiX Welcomes Dr Bjorn Dahl

Wishing Everyone Happy Holidays

The ApconiX team enjoyed a festive lunch at the Coach and Four in Wilmslow this Christmas. We'd all like to take this opportunity to wish everyone Happy Holidays, a Merry Christmas and a very Happy and Prosperous New Year. Here's to making lots of better decisions in 2019!

By |2018-12-21T17:20:41+00:00December 16th, 2018|Events|Comments Off on Wishing Everyone Happy Holidays

Choosing the right non-clinical CRO

Non-clinical contract research organisations (CROs) are an integral part of modern drug development. For any novel agent, delivery of GLP toxicity data to support clinical trials is a crucial step that requires a professional organisation with dedicated management, infrastructure and a broad array of technical and scientific skills. In selecting a CRO, the sponsor typically [...]

By |2018-09-12T14:07:14+01:00September 19th, 2018|Toxicology, Press|Comments Off on Choosing the right non-clinical CRO

ApconiX Celebrates EUROTOX

EUROTOX 2018 was a great success with many excellent sessions, posters and keynote lectures.  There were more than 1400 attendees from >50 countries giving an outstanding opportunity for networking and learning. Highlights included the Merit award lecture from Sam Cohen (University of Nebraska) who talked about “Cell proliferation and carcinogenesis” and the HESI CITE lecture [...]

By |2018-09-13T08:39:22+01:00September 12th, 2018|Events|Comments Off on ApconiX Celebrates EUROTOX

Paul Duffy Presents at EUROTOX 2018

Dr Paul Duffy will be speaking at EUROTOX this September. On Monday 3rd of September at 16:30 in the SILVER Hall Paul will address “Old drugs in new guises: the toxicology of repurposing” chaired and introduced by Ruth Roberts and Dr Miranda Cornet from UCB in Belgium.  Paul will present case studies to illustrate the [...]

By |2018-08-23T12:05:58+01:00August 22nd, 2018|Toxicology, Events|Comments Off on Paul Duffy Presents at EUROTOX 2018

Safety Must Be Prioritized In Drugs for Cancer

Despite the fact that the number of diagnosed cases of malignant mesothelioma are expected to rise in the next decades, there has been little real progress in available treatments, and the chemotherapy drug used to treat the disease is the same one that has been used for the last several  years. Though there is a [...]

By |2018-07-11T10:00:27+01:00May 16th, 2018|Press|Comments Off on Safety Must Be Prioritized In Drugs for Cancer

Preclinical Safety in Cancer Drug Development: “Attitude to Safety Needs to Change”

Many companies involved in cancer drug research and development need to re-think their use of safety data in helping to bring new drugs to cancer patients. Dr Richard Knight of Alderley Park-based ApconiX told last month’s conference, Accelerating Cancer Drug Development – from target to patients, that greater focus on pre-clinical safety should be fundamental to [...]

By |2018-07-11T10:12:48+01:00March 27th, 2018|Toxicology|Comments Off on Preclinical Safety in Cancer Drug Development: “Attitude to Safety Needs to Change”

Accelerating Cancer Drug Development

Accelerating Cancer Drug Development -From target to patients, BioNow will be hosting this event at Alderley Park on the 27th of February 2018. Focusing upon the strengths in the discovery, development and manufacture of cancer medicines in the North of England through to commercialisation (patients), this event will highlight industry, academic and clinical strengths whilst [...]

By |2018-07-11T11:58:57+01:00February 27th, 2018|Events|Comments Off on Accelerating Cancer Drug Development

XenoGesis and Sygnature Discovery to Host Meeting

XenoGesis is teaming up with Sygnature Discovery and DMDG to host the forthcoming meeting on predictive toxicology in Discovery DMPK. The one-day meeting will be held at BioCity, Nottingham on Thursday 22nd March 2018. The meeting will provide a forum for the exchange of ideas between members of the DMPK and toxicology research communities. The event will bring together talks from thought [...]

By |2018-07-11T12:06:23+01:00February 22nd, 2018|Events|Comments Off on XenoGesis and Sygnature Discovery to Host Meeting

Attitude Toward Safety in Needs to Change

A co-founder of the company ApconiX, based in Alderley Park, has revealed his view that attitude towards safety in pre-clinical cancer drug development needs to change. “There is still huge unmet need in effective cancer treatment and it can be tempting for companies researching new drugs to focus mainly on efficacy data with safety issues [...]

By |2018-06-27T16:32:28+01:00February 20th, 2018|Press|Comments Off on Attitude Toward Safety in Needs to Change