The challenge The U.S. Food and Drug Administration's National Center for Toxicological Research (NCTR) is a global resource for collaboration providing consultation, training, and innovative scientific solutions in support of FDA's mission to improve public health. Within NCTR, The Division of Bioinformatics and Biostatistics is developing bioinformatics methodologies and standards to support FDA research and [...]

The challenge Redx Pharma is a drug discovery and development company focused on creating new drugs for areas of unmet medical need such as cancer and immunology.  As their portfolio rapidly matured, Redx recognised a need for expert safety input as well as ion channel screening data, to develop high quality clinical candidates. The solution [...]

The challenge Blueberry Therapeutics is a dermatology biotech company developing innovative topical drugs for a range of diseases, using a novel ‘nano-delivery’ platform. This technique significantly enhances the penetration of drugs into cells and tissues. ApconiX was set the challenge to provide guidance on the most appropriate nonclinical safety studies needed to support the [...]

"I’ve worked with Guy Healing for the last year on CTA/IND enabling toxicology studies for 2 compounds.  Guy did a fabulous job as a study monitor and toxicology consultant for the 15 studies in total placed at CROs in UK and Germany.  As I am based in the US, Guy was pivotal in bridging [...]

“It has been a tremendous pleasure to work with Ruth @ApconiX for the past year. Her in-depth knowledge in toxicology in general and drug discovery/development in specific has contributed significantly to my division’s research in the area of drug-induced liver injury and in vitro to in vivo extrapolation.  I am expecting much great science [...]

“ApconiX has provided hERG data to Redx Pharma from June 2016 to help support our discovery projects. Data turnaround times over this period have been rapid (under 1 week) and this has been critical in progressing projects quickly; outsourcing the assay with this turn-around has had no impact on our "design-make-test" cycle times. Additionally, ApconiX’s approach is very collaborative providing [...]

"The support that we received from the ApconiX team has been excellent and they have helped us both in developing our nonclinical safety thinking and in providing direct support for the clinical trial application. We’re looking forward to continuing our collaboration as we progress our exciting new medicines into later-stage development and hopefully the [...]

"ApconiX target reviews are of outstanding quality and obviously created by people with a thorough understanding of what is needed to help guide decisions"

“Your data turnaround time is incredibly good and it really helps us track the SAR and progress our compounds in a rapid and efficient manner. Thanks ApconiX for your wonderful support to Bugworks.”

“We are delighted to have found a flexible way to access specialist technical expertise and operational support to complement our existing internal capabilities to support the ongoing development of our lead product, SFX-01.  We selected this excellent group of providers as our partners as they have a proven track record of working well together [...]