De novo LINE-1 Retrotransposition in HepG2 Cells Preferentially Targets Gene Poor Regions of Chromosome 13. Genomics. 104, 96-104.
Longinterspersednuclear elements(Line-1 orL1s) account for~17% of thehuman genome. While the majority ofhuman L1s are inactive, ~80–100 elements remain retrotransposition competent and mobilize through RNAintermediates to different locations within the genome. De novo insertions of L1s account for polymorphicvariation of the human genome and disruption of target loci at their new location…
By Chloe Atkinson|2022-11-28T14:11:30+00:00June 17th, 2021|Comments Off on De novo LINE-1 Retrotransposition in HepG2 Cells Preferentially Targets Gene Poor Regions of Chromosome 13. Genomics. 104, 96-104.