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1663: Target Safety Assessments: Evaluation of the Toxicological Risk of Targeting FRS (Phenylalanyl-tRNA Synthetase) in the Treatment of Malaria. Authors: J. Barber1, C. Sadler1, D. Baud2, P. Willis2, and R. Roberts1,3.

 1ApconiX, Alderley Edge, United Kingdom; 2Medicines for Malaria Venture, Geneva, Switzerland; and 3University of Birmingham, Birmingham, United Kingdom.

Talk by Jane Barber as part of the Safety Assessment: Pharmaceutical—Drug Discovery I Platform. 

Monday March 11th 1:45pm – 2:00pm 
Conference Center Room 321 

Read abstract here

Get in TOUCH

Alderley Park
Alderley Edge
SK10 4TG

ApconiX will be exhibiting at the 58th Annual Meeting of the Society of Toxicology in Baltimore. Michael Morton, Ruth Roberts, Richard Knight, Jane Barber, Paul Duffy, Steffen Ernst and Marie Cumberbatch will all be there. Come and meet us at booth 2610. 

The ApconiX team will be giving talks and presenting workshops and posters during the meeting. Here are some of the highlights: 

2613: New Opportunities for a Psychoactive Psilocybin in Neuropsychopharmacological Clinical Disorders. Authors: P. A. Duffy1, S. Stansfield2, G. Healing1, R. Knight1, and R. A. Roberts1,3

1ApconiX, Alderley Edge, United Kingdom; 2COMPASS Pathways, London, United Kingdom; and 3University of Birmingham, Birmingham, United Kingdom. 

Talk by Paul Duffy as part of the Safety Assessment: Pharmaceutical—Drug Development I Platform 

Wednesday March 13th 9:15am – 9:30am 
Conference Center Room 321 

Read abstract here

The 58th Annual Meeting of the Society of Toxicology in Baltimore runs from 10th to the 14th March.

Visit SOT 2019 website

Talk by Jane Barber as part of the Safety Assessment: Pharmaceutical—Drug Discovery I Platform. 

Monday March 11th 
1:45pm – 2:00pm 
Conference Center Room 321 

1663: Target Safety Assessments: Evaluation of the Toxicological Risk of Targeting FRS (Phenylalanyl-tRNA Synthetase) in the Treatment of Malaria. Authors: J. Barber1, C. Sadler1, D. Baud2, P. Willis2, and R. Roberts1,3.

 1ApconiX, Alderley Edge, United Kingdom; 2Medicines for Malaria Venture, Geneva, Switzerland; and 3University of Birmingham, Birmingham, United Kingdom. 

Read abstract here

Talk by Paul Duffy as part of the Safety Assessment: Pharmaceutical—Drug Development I Platform 

Wednesday March 13th
9:15am – 9:30am
Conference Center Room 321 

2613: New Opportunities for a Psychoactive Psilocybin in Neuropsychopharmacological Clinical Disorders. Authors: P. A. Duffy1, S. Stansfield2, G. Healing1, R. Knight1, and R. A. Roberts1,3

1ApconiX, Alderley Edge, United Kingdom; 2COMPASS Pathways, London, United Kingdom; and 3University of Birmingham, Birmingham, United Kingdom.  

Read abstract here

Talk by Michael Morton as part of the Workshop ‘Can we panelise seizure’?

Wednesday March 13th 9:30am – 10:00am 
Conference Center 
Ballroom III 
Innovations in Applied Toxicology

2588: Using Ion Channels to Panelize Seizure: Where Are We Up To? 

Authors: M. Morton. ApconiX, Alderley Edge, United Kingdom. Sponsor: J. Pierson

Read abstract here
Visit SOT 2019 website

The 58th Annual Meeting of the Society of Toxicology in Baltimore runs from 10th to the 14th March.

2588: Using Ion Channels to Panelize Seizure: Where Are We Up To? 

Authors: M. Morton. ApconiX, Alderley Edge, United Kingdom. Sponsor: J. Pierson

Talk by Michael Morton as part of the Workshop ‘Can we panelise seizure’?

Wednesday March 13th 9:30am – 10:00am 
Conference Center Ballroom III

Innovations in Applied Toxicology

Read abstract here

Talks

Posters

Talks

Posters

2072: Incorporating the CiPA Paradigm into an Integrated Cardiac Risk Assessment. 

Authors: M. Morton1, R. Printemps2, M. Le Grand2, M. Davies3, and R. Roberts1.

1ApconiX Ltd, Alderley Park, United Kingdom; 2PhysioStim, Toulouse, France; and 3QT Informatics Ltd., Alderley Park, United Kingdom.  

Presented by Richard Printemps of PhysioStim 
Poster Board – P463 - Conference Center Exhibition Hall 

Tuesday March 12th 3:00pm – 4:30pm 

Read abstract here

1780: Drug-Induced Liver Injury Severity and Toxicity (DILIst): Binary Classification of 1379 Drugs by Human. 

Authors: S. Thakkar1, T. Li1, L. Wu1, Z. Liu1, R. Roberts2, and W. Tong1.

1US FDA/NCTR, Jefferson, AR; and 2ApconiX Ltd, Alderley Park, Alderley Edge, United Kingdom.

Presented by Shraddha Thakker of FDA NCTR
Poster Board – P156

Conference Center Exhibition Hall

Tuesday March 12th 10:45am - 12:15pm

Read abstract here

1811: Repurposing Immortalized Cell Line-Based Transcriptomic Profiling Assays for Drug-Induced Liver Injury with a PRank Method. 

Authors: Z. Liu1, R. Roberts2, and W. Tong1.

1US FDA/NCTR, Jefferson, AR; and 2ApconiX Ltd, Alderley Park, Alderley Edge, United Kingdom.

Presented by Zhichao Liu of FDA NCTR
Poster Board – P190

Conference Center Exhibition Hall

Tuesday March 12th 1:30pm - 3:00pm

Read abstract here

1448: Classification of Drug-Induced Seizure-Like Activities in Cultured Human iPSC-Derived Neurons. 

Authors: Y. Ishibashi, A. Odawara, N. Matsuda, and I. Suzuki. 
Tohoku Institute of Technology, Sendai, Miyagi, Japan.

Sponsor: R. Roberts

Poster Board – P517
Conference Center Exhibition Hall

Read abstract here

1449: TRP Channel Responses in Human iPSC-Derived Sensory Neurons Using MEA System.

Authors: A. Odawara, Y. Kobayashi, N. Matsuda, and I. Suzuki.
Tohoku Institute of Technology, Sendai, Miyagi, Japan.

Sponsor: R. Roberts

Poster Board – P518
Conference Center Exhibition Hall

Read abstract here

1455: Real-Time Measurement of Drug Release Using Carbon Nanotube MEA System.

Authors:  N. Matsuda, A. Odawara, K. Ogawa, and I. Suzuki. 
Tohoku Institute of Technology, Sendai, Miyagi, Japan.

Sponsor: R. Roberts

Poster Board – P524
Conference Center Exhibition Hall

Read abstract here

Posters - Monday March 11th 10:45am - 12:15pm Sponsored by Ruth Roberts

2072: Incorporating the CiPA Paradigm into an Integrated Cardiac Risk Assessment. 

Authors: M. Morton1, R. Printemps2, M. Le Grand2, M. Davies3, and R. Roberts1.

1ApconiX Ltd, Alderley Park, United Kingdom; 2PhysioStim, Toulouse, France; and 3QT Informatics Ltd., Alderley Park, United Kingdom.  

Presented by Richard Printemps of PhysioStim 

Read abstract here

Poster Board – P463
Conference Center Exhibition Hall 

Tuesday March 12th 
3:00pm – 4:30pm 

1780: Drug-Induced Liver Injury Severity and Toxicity (DILIst): Binary Classification of 1379 Drugs by Human. 

Authors: S. Thakkar1, T. Li1, L. Wu1, Z. Liu1, R. Roberts2, and W. Tong1.

1US FDA/NCTR, Jefferson, AR; and 2ApconiX Ltd, Alderley Park, Alderley Edge, United Kingdom.

Presented by Shraddha Thakker of FDA NCTR
Poster Board – P156

Conference Center Exhibition Hall

Tuesday March 12th 10:45am - 12:15pm

Read abstract here

1811: Repurposing Immortalized Cell Line-Based Transcriptomic Profiling Assays for Drug-Induced Liver Injury with a PRank Method. 

Authors: Z. Liu1, R. Roberts2, and W. Tong1.

1US FDA/NCTR, Jefferson, AR; and 2ApconiX Ltd, Alderley Park, Alderley Edge, United Kingdom.

Presented by Zhichao Liu of FDA NCTR
Poster Board – P190

Conference Center Exhibition Hall

Tuesday March 12th 
1:30pm - 3:00pm

Read abstract here

Posters
Monday March 11th 10:45am - 12:15pm Sponsored by Ruth Roberts

1448: Classification of Drug-Induced Seizure-Like Activities in Cultured Human iPSC-Derived Neurons. 

Authors: Y. Ishibashi, A. Odawara, N. Matsuda, and I. Suzuki. 
Tohoku Institute of Technology, Sendai, Miyagi, Japan.

Sponsor: R. Roberts

Poster Board – P517
Conference Center Exhibition Hall

Read abstract here

1449: TRP Channel Responses in Human iPSC-Derived Sensory Neurons Using MEA System.

Authors: A. Odawara, Y. Kobayashi, N. Matsuda, and I. Suzuki.
Tohoku Institute of Technology, Sendai, Miyagi, Japan.

Sponsor: R. Roberts

Poster Board – P518
Conference Center Exhibition Hall

Read abstract here

Poster Board – P524
Conference Center Exhibition Hall

Read abstract here

1455: Real-Time Measurement of Drug Release Using Carbon Nanotube MEA System.

Authors:  N. Matsuda, A. Odawara, K. Ogawa, and I. Suzuki. 
Tohoku Institute of Technology, Sendai, Miyagi, Japan.

Sponsor: R. Roberts