For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery.
Join Dr Michael Morton, Director and Co-founder of ApconiX in a live webinar on Thursday, November 19th 2020 at 11am EST (4pm GMT).
In this free webinar, hosted by Xtalks, attendees will learn about the importance of ion channels in drug discovery and how this is evolving. Mike will discuss advances in ion channel biology, experimental technologies and in vitro models, new ion channel ligands and toxicological considerations.
There are over 200 ion channels in the human body, all playing a pivotal role in normal physiology. As such, they are important targets for drug therapies that modulate ion channels in critical pathways, or correct aberrant ion channel function. To date, there are over 150 marketed drugs that target ion channels. Many of these drugs are anaesthetics, anti-epileptics or are active in the cardiovascular system.
The importance of ion channels in the pharmaceutical industry is evolving. As knowledge of ion channel physiology and how to target ion channels evolves, therapeutic opportunities are becoming more diverse, extending to renal and respiratory disease, inflammation, cancer, pain and depression. How the pharmaceutical industry tests and explores ion channels is also evolving with high-throughput platforms and hiPSC models.
Targeting ion channels selectively has always been challenging. New, more specific modalities including antibodies, aptamers, peptides and knotbodies are also being explored. Finally, given the importance of ion channels in normal physiology, unwanted activity at ion channels in the heart or CNS can cause serious adverse effects and should be avoided. In this respect, screening for effects on ion channels is a key, rapidly developing area of drug discovery.
Consideration of these evolving areas in ion channel drug discovery is critical to the successful development of new medicines.
For more information, or to register for this event, visit The Evolving Role of Ion Channels in Shaping Successful Drug Discovery.
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